Document Detail

First-aid treatment of anaphylaxis to food: focus on epinephrine.
MedLine Citation:
PMID:  15131564     Owner:  NLM     Status:  MEDLINE    
Avoiding food triggers for anaphylactic reactions (severe acute systemic allergic reactions) is easier said than done. Most episodes of anaphylaxis to food occur unexpectedly in the community in the absence of a health care professional. All individuals at risk should therefore have an emergency action plan in place. The cornerstone of first-aid treatment of anaphylaxis is epinephrine injected intramuscularly in the vastus lateralis muscle (lateral aspect of the thigh). In this review, we focus on epinephrine. We examine a therapeutic dilemma: the issue of epinephrine dose selection in an individual for whom no optimal fixed-dose auto-injector formulation exists, and a therapeutic controversy: the issue of epinephrine injection versus an oral H1-antihistamine in anaphylaxis episodes that appear to be mild. The pharmaceutical industry could address the first of these issues by providing a wider range of epinephrine fixed doses in easy-to-use auto-injectors, or by providing adjustable epinephrine doses in auto-injectors. The second issue could be addressed in part by development of alternative routes of epinephrine administration for the first-aid, out-of-hospital treatment of anaphylaxis.
F Estelle R Simons
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  113     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-07     Completed Date:  2004-06-17     Revised Date:  2009-05-22    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  837-44     Citation Subset:  AIM; IM    
Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada R3A 1R9.
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MeSH Terms
Administration, Oral
Anaphylaxis / drug therapy*
Charcoal / therapeutic use
Epinephrine / administration & dosage,  therapeutic use*
Evidence-Based Medicine
First Aid
Food Hypersensitivity / drug therapy*
Histamine H1 Antagonists / administration & dosage
Injections, Intramuscular / instrumentation
Reg. No./Substance:
0/Histamine H1 Antagonists; 16291-96-6/Charcoal; 51-43-4/Epinephrine
Comment In:
J Allergy Clin Immunol. 2004 Jul;114(1):127-30   [PMID:  15241355 ]
Erratum In:
J Allergy Clin Immunol. 2004 Jun;113(6):1039
Note: Dosage error in article text

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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