Document Detail


First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia.
MedLine Citation:
PMID:  20733087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies report an association between vitamin D deficiency and hypertension, including the pregnancy-specific disorder preeclampsia. Circulating vitamin D is almost entirely bound to vitamin D binding protein, which increases 2-fold during pregnancy and previous studies have not examined vitamin D binding protein or free vitamin D levels. We performed a nested case-control study within the Massachusetts General Hospital Obstetric Maternal Study, measuring first trimester total 25-hydroxyvitamin D (25[OH]D) and vitamin D binding protein and calculating free 25(OH)D levels. We compared these levels from pregnancies complicated by subsequent preeclampsia (cases, n=39) with those from normotensive pregnancies (controls, n=131). First trimester total 25(OH)D levels were similar in cases and controls (27.4±1.9 versus 28.8±0.80 ng/mL; P=0.435). Despite an association between higher first trimester blood pressures and subsequent preeclampsia, first trimester total 25(OH)D was not associated with first trimester systolic (r=0.11; P=0.16) or diastolic blood pressures (r=0.03; P=0.72). Although there was a trend toward increased risk of preeclampsia with 25(OH)D levels <15 ng/mL (odds ratio: 2.5 [95% CI: 0.89 to 6.90]), this was attenuated after adjustment for body mass index and other covariates (odds ratio: 1.35 [95% CI: 0.40 to 4.50]). First trimester vitamin D binding protein and free 25(OH)D levels were similar in cases and controls and were not associated with first trimester blood pressures. These data suggest that first trimester total and free 25(OH)D levels are not independently associated with first trimester blood pressure or subsequent preeclampsia.
Authors:
Camille E Powe; Ellen W Seely; Sarosh Rana; Ishir Bhan; Jeffrey Ecker; S Ananth Karumanchi; Ravi Thadhani
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-23
Journal Detail:
Title:  Hypertension     Volume:  56     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2010-10-29     Revised Date:  2013-09-20    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  758-63     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Blood Pressure
Case-Control Studies
Female
Gestational Age
Humans
Pre-Eclampsia / blood*,  physiopathology
Pregnancy
Pregnancy Trimester, First / blood*
Risk Assessment
Vitamin D / blood*
Vitamin D-Binding Protein / blood*
Young Adult
Grant Support
ID/Acronym/Agency:
K12HD001255/HD/NICHD NIH HHS; K24 HL096141/HL/NHLBI NIH HHS; K24HL096141/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Vitamin D-Binding Protein; 1406-16-2/Vitamin D
Comments/Corrections

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