Document Detail


First Trimester Metabolomic Detection of Late-Onset Preeclampsia.
MedLine Citation:
PMID:  23159745     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To identify first trimester maternal serum biomarkers for the prediction of late-onset preeclampsia (PE) using metabolomic analysis. STUDY DESIGN: In a case-control study, NMR based metabolomic analysis was performed on first trimester maternal serum between 11-13 6/7 weeks of gestation in a case-control study. There were 30 cases of late onset preeclampsia, i.e. requiring delivery = 37 weeks, and 59 unaffected controls. The concentrations of 40 metabolites were compared between the two groups. We also compared 30 early-onset to the late-onset group. RESULTS: A total of 14 metabolites were significantly elevated and 3 significantly reduced in first-trimester serum of late-onset PE patients. A complex model consisting of multiple metabolites and maternal demographic characteristics had a 76.6% sensitivity at 100% specificity for PE detection. A simplified model using fewer predictors yielded 60% sensitivity at 96.6% specificity. Strong separation of late vs early onset PE groups were achieved. CONCLUSION: Significant differences in the first-trimester metabolites were noted in women who went on to developed late-onset PE and between early- and late-onset PE.
Authors:
Ray O Bahado-Singh; Ranjit Akolekar; Rupasri Mandal; Edison Dong; Jianguo Xia; Michael Kruger; David S Wishart; Kypros Nicolaides
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  -     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Mosby, Inc.
Affiliation:
Department of Obstetrics and Gynecology, Wayne State University, MI, USA. Electronic address: rbahados@med.wayne.edu.
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