Document Detail

First-Trimester Levels of Pregnancy-Associated Plasma Protein A2 (PAPP-A2) in the Maternal Circulation Are Elevated in Pregnancies That Subsequently Develop Preeclampsia.
MedLine Citation:
PMID:  24336677     Owner:  NLM     Status:  Publisher    
Recent studies have consistently found pregnancy-associated plasma protein A2 (PAPP-A2) to be upregulated in preeclamptic placentae at term. We tested whether first-trimester circulating PAPP-A2 levels differed between complicated and uncomplicated pregnancies. We measured maternal PAPP-A2 levels at 10 to 14 weeks of gestational age in 17 pregnancies resulting in small-for-gestational-age (SGA) infants, 6 which developed preeclampsia (PE), 1 which developed PE and resulted in an SGA infant, and 37 gestational age-matched controls. The concentration of the PAPP-A2 isoform corresponding to the full-length protein was significantly higher in pregnancies that developed PE (35 ng/mL) compared with those that did not (23 ng/mL; P < .044). In contrast, we found no difference in PAPP-A2 levels between pregnancies that did or did not result in an SGA infant. The upregulation of PAPP-A2 that has previously been observed in PE at term appears to begin early in pregnancy, well before the symptoms develop.
Erin J Crosley; Ursula Durland; Ken Seethram; Scott Macrae; Andrée Gruslin; Julian K Christians
Related Documents :
12421167 - Bacterial vaginosis in early pregnancy may predispose for preterm birth and postpartum ...
15511757 - Predictive value of amniotic fluid and fetal blood cultures in pregnancy outcome in pre...
14533897 - Treatment of previable premature ruptured membranes.
18720037 - Ivf pregnancies: neonatal outcomes after the new italian law on assisted reproduction t...
19859897 - Giant placental chorioangioma: natural history and pregnancy outcome.
22378227 - Maternal nutrient intakes and levels of energy underreporting during early pregnancy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-13
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  -     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Maternal and Fetal Outcomes in Placenta Accreta After Institution of Team-Managed Care.
Next Document:  Increased Expression of Kindlin 2 in Luteinized Granulosa Cells Correlates With Androgen Receptor Le...