Document Detail

First- and second-trimester screening for preeclampsia and intrauterine growth restriction.
MedLine Citation:
PMID:  20638585     Owner:  NLM     Status:  MEDLINE    
Preeclampsia and intrauterine growth restriction are major contributors to perinatal mortality and morbidity. Accurate prediction is important for identifying those women who require more intensive monitoring, permitting earlier recognition and intervention, and allowing targeting of potential preventive measures to those at risk. Although different measures of placental dysfunction have been associated with increased risk adverse pregnancy outcomes, the ability of any single one to accurately predict these outcomes is poor. Attempts to use predictive models combining analytes and measurements of placental structure and blood flow have so far produced mixed results. The use of first- and second-trimester biochemical markers in combination with uterine artery Doppler screening shows promise as potential screening tools. Large prospective studies are needed to further evaluate the choice of parameters and strategies of combination to achieve the best predictive models.
Methodius G Tuuli; Anthony O Odibo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in laboratory medicine     Volume:  30     ISSN:  1557-9832     ISO Abbreviation:  Clin. Lab. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100174     Medline TA:  Clin Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  727-46     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Division of Maternal-Fetal Medicine and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, Campus 4566 Scott Avenue, St Louis, MO 63110, USA.
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MeSH Terms
Fetal Growth Retardation / diagnosis*
Mass Screening
Pre-Eclampsia / diagnosis*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prenatal Diagnosis*

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