Document Detail


First report of the successful use of bosentan in refractory vasospastic angina.
MedLine Citation:
PMID:  20424449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Variant angina is caused by focal spasm of the epicardial coronary arteries and is variably associated with atherosclerotic coronary disease. We present the clinical course of profound coronary spasm in a woman which resulted in life-threatening symptoms. Although not previously reported, administration of the endothelin antagonist bosentan resulted in complete resolution of her symptoms which were refractory to commonly used anti-anginals, and these symptoms recurred when the drug was inadvertently withdrawn, confirming efficacy of the agent. The details of her clinical outcome and a review of the role of endothelin and its antagonists in coronary vasospasm are discussed.
Authors:
Unni Krishnan; Wutyee Win; Michael Fisher
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-04-27
Journal Detail:
Title:  Cardiology     Volume:  116     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-04     Completed Date:  2010-09-16     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  26-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 S. Karger AG, Basel.
Affiliation:
Department of Cardiology, Royal Liverpool University Hospital, Liverpool, UK. unni.krishnan@nhs.net
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MeSH Terms
Descriptor/Qualifier:
Angina Pectoris, Variant / drug therapy*,  etiology,  metabolism
Antihypertensive Agents / therapeutic use*
Coronary Vasospasm / complications,  drug therapy*,  metabolism
Endothelins / antagonists & inhibitors*,  metabolism
Female
Humans
Middle Aged
Sulfonamides / therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Endothelins; 0/Sulfonamides; Q326023R30/bosentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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