Document Detail


First report of the successful use of bosentan in refractory vasospastic angina.
MedLine Citation:
PMID:  20424449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Variant angina is caused by focal spasm of the epicardial coronary arteries and is variably associated with atherosclerotic coronary disease. We present the clinical course of profound coronary spasm in a woman which resulted in life-threatening symptoms. Although not previously reported, administration of the endothelin antagonist bosentan resulted in complete resolution of her symptoms which were refractory to commonly used anti-anginals, and these symptoms recurred when the drug was inadvertently withdrawn, confirming efficacy of the agent. The details of her clinical outcome and a review of the role of endothelin and its antagonists in coronary vasospasm are discussed.
Authors:
Unni Krishnan; Wutyee Win; Michael Fisher
Related Documents :
12405579 - A case of coronary spasm induced by 5-fluorouracil.
8043979 - Ventricular fibrillation related to coronary spasm in patients without significant coro...
19685519 - Long-term prognosis of non-interventionally followed patients with isolated myocardial ...
6199449 - Asthma induced myocardial infarction in a patient with normal coronary arteries: a case...
6613809 - Catheter-induced coronary artery spasm: an angiographic manifestation of vasospastic an...
2297959 - Coronary artery spasm induced by anesthesia: a case report and review of the literature.
15336999 - Selecting patients with mitral regurgitation and left ventricular dysfunction for isola...
16159859 - Mri to evaluate left atrial and ventricular reverse remodeling after restrictive mitral...
17172929 - Coronary blood flow in patients with cardiac syndrome x.
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-04-27
Journal Detail:
Title:  Cardiology     Volume:  116     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-04     Completed Date:  2010-09-16     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  26-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 S. Karger AG, Basel.
Affiliation:
Department of Cardiology, Royal Liverpool University Hospital, Liverpool, UK. unni.krishnan@nhs.net
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angina Pectoris, Variant / drug therapy*,  etiology,  metabolism
Antihypertensive Agents / therapeutic use*
Coronary Vasospasm / complications,  drug therapy*,  metabolism
Endothelins / antagonists & inhibitors*,  metabolism
Female
Humans
Middle Aged
Sulfonamides / therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Endothelins; 0/Sulfonamides; Q326023R30/bosentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Animal Models Related to Congenital Heart Disease and Clinical Research in Pulmonary Hypertension.
Next Document:  Low-Voltage Electrocardiogram in Patients with Hypothyroidism and Pericardial Effusion: Can Serial C...