| First report of the successful use of bosentan in refractory vasospastic angina. | |
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MedLine Citation:
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PMID: 20424449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Variant angina is caused by focal spasm of the epicardial coronary arteries and is variably associated with atherosclerotic coronary disease. We present the clinical course of profound coronary spasm in a woman which resulted in life-threatening symptoms. Although not previously reported, administration of the endothelin antagonist bosentan resulted in complete resolution of her symptoms which were refractory to commonly used anti-anginals, and these symptoms recurred when the drug was inadvertently withdrawn, confirming efficacy of the agent. The details of her clinical outcome and a review of the role of endothelin and its antagonists in coronary vasospasm are discussed. |
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Authors:
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Unni Krishnan; Wutyee Win; Michael Fisher |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-04-27 |
Journal Detail:
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Title: Cardiology Volume: 116 ISSN: 1421-9751 ISO Abbreviation: Cardiology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 26-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Cardiology, Royal Liverpool University Hospital, Liverpool, UK. unni.krishnan@nhs.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angina Pectoris, Variant
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drug therapy*,
etiology,
metabolism Antihypertensive Agents / therapeutic use* Coronary Vasospasm / complications, drug therapy*, metabolism Endothelins / antagonists & inhibitors*, metabolism Female Humans Middle Aged Sulfonamides / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Endothelins; 0/Sulfonamides; 147536-97-8/bosentan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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