Document Detail

First report of the successful use of bosentan in refractory vasospastic angina.
MedLine Citation:
PMID:  20424449     Owner:  NLM     Status:  MEDLINE    
Variant angina is caused by focal spasm of the epicardial coronary arteries and is variably associated with atherosclerotic coronary disease. We present the clinical course of profound coronary spasm in a woman which resulted in life-threatening symptoms. Although not previously reported, administration of the endothelin antagonist bosentan resulted in complete resolution of her symptoms which were refractory to commonly used anti-anginals, and these symptoms recurred when the drug was inadvertently withdrawn, confirming efficacy of the agent. The details of her clinical outcome and a review of the role of endothelin and its antagonists in coronary vasospasm are discussed.
Unni Krishnan; Wutyee Win; Michael Fisher
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-04-27
Journal Detail:
Title:  Cardiology     Volume:  116     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-04     Completed Date:  2010-09-16     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  26-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 S. Karger AG, Basel.
Department of Cardiology, Royal Liverpool University Hospital, Liverpool, UK.
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MeSH Terms
Angina Pectoris, Variant / drug therapy*,  etiology,  metabolism
Antihypertensive Agents / therapeutic use*
Coronary Vasospasm / complications,  drug therapy*,  metabolism
Endothelins / antagonists & inhibitors*,  metabolism
Middle Aged
Sulfonamides / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents; 0/Endothelins; 0/Sulfonamides; Q326023R30/bosentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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