Document Detail


Fipronil-induced cell death in salivary glands of Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae) semi-engorged females.
MedLine Citation:
PMID:  20974132     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The tick Rhipicephalus sanguineus is currently considered an urban plague. For this reason many studies are intended to find methods to control these ectoparasites. Thus, the present study analyzed the ultrastructural modifications of the salivary glands cells of semi-engorged females of R. sanguineus resulting from their exposition to Fipronil (active ingredient of Frontline®). The studied individuals were divided into four groups. Group 1 was exposed to distilled water (control) and groups 2, 3 and 4 were exposed to 1, 5 and 10ppm of Fipronil, respectively. The salivary gland of ticks subjected to the acaricide showed accelerated process of cell death by atypical apoptosis, as well as augmented cell damages as the concentration of the chemical compound was increased. The acaricide toxicity at cellular level was demonstrated by remarkable changes of elements of the cytoskeleton and spherocrystals (extremely hard inorganic structures). However, tick defense mechanisms, such as the observed autofagic vacuoles proved the cells attempt to preserve their integrity and minimize the devastating action of this chemical compound on the salivary glands.
Authors:
Carolina Parga Martins Pereira; Patrícia Rosa de Oliveira; Karim Christina Scopinho Furquim; Gervásio Henrique Bechara; Maria Izabel Camargo-Mathias
Publication Detail:
Type:  Journal Article     Date:  2010-10-23
Journal Detail:
Title:  Experimental parasitology     Volume:  127     ISSN:  1090-2449     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  481-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Biology, Institute of Biosciences, São Paulo State University-UNESP, Av. 24 A, No. 1515, Postal Code 199, 13506-900 Rio Claro, SP, Brazil.
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