| Finite-element modeling of microsphere surface modes and high-frequency ultrasound scattering from a single cell. | |
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MedLine Citation:
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PMID: 18189659 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A finite-element model of wave propagation using COMSOL Multiphysics (COMSOL Inc., Burlington, MA) was developed to solve the problem of high-frequency ultrasound (10-70 MHz) scattering from spheres. This model is being used to predict ultrasound backscatter from cells for ultrasound tissue characterization. In this work, backscatter from an elastic (polystyrene) microsphere was used to validate the computational model against experimental results. Agreement between experimental results and finite-element solutions were found in the frequency domain solutions. Moreover, conversion of the theoretical solutions to time-domain backscatter data showed good agreement with experimental time domain measurements. To develop a better understanding of the interactions of the incident pressure field with the scattering object, oscillations of the elastic microsphere at various resonance frequencies were also investigated. A systematic relationship between the resonance frequency and its corresponding surface mode was found. An ultrasound scattering model by a single cell is also presented. The model treats the cell as an elastic sphere (nucleus) surrounded by a fluid shell (cytoplasm). Comparison of the theoretical backscatter predicted by the model and experimental measurements for acute Myeloid Leukemia (AML) cell is also shown. Finally, the implications of these results on ultrasound tissue characterization techniques are discussed. |
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Authors:
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Omar Falou; J Carl Kumaradas; Michael C Kolios |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 122 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2008-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 2957 Citation Subset: IM |
Affiliation:
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Dept. of Elec. and Comput. Eng., Ryerson Univ., 350 Victoria St., Toronto, ON, Canada, M5B 2K3Ryerson Univ., Toronto, ON, Canada, M5B 2K3. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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