Document Detail

Finite element analysis of the mechanical behavior of preterm lamb tracheal bifurcation during total liquid ventilation.
MedLine Citation:
PMID:  23177086     Owner:  NLM     Status:  Publisher    
Knowledge of the mechanical behavior of immature airways is crucial to understand the effects exerted by ventilation treatments, namely by Total Liquid Ventilation (TLV). A computational approach was adopted to investigate preterm airways in the range of pressure applied during TLV. A 3D finite-element model of the tracheal bifurcation was developed. Structural analyses were performed using ABAQUS/Standard to evaluate airway deformation during TLV. The model consists of 7 rings, each composed of 3 tissues (cartilage, smooth muscle, connective tissue) modeled as hyperelastic materials. Biomechanical experimental tests were performed on lamb tracheae to obtain the stress-strain relationship for each tissue. Pressure load was applied on the internal surface of the model, reproducing the airway pressure tracing acquired during a TLV breath ending with a tracheal collapse phenomenon. Model reliability was verified by comparing the model outcomes to computer tomography scan images acquired during animal TLV trials. The simulations show progressive lumen narrowing during expiration, at increasing negative pressure until the occurrence of collapse; however not inducing complete airway occlusion. A reliable model was obtained to help setting ventilation parameters during TLV.
Paola Bagnoli; Fabio Acocella; Mauro Di Giancamillo; Roberto Fumero; Maria Laura Costantino
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-21
Journal Detail:
Title:  Journal of biomechanics     Volume:  -     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
LaBS-Laboratory of Biological Structures Mechanics, Department of Structural Engineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy. Electronic address:
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