| Finite element model of the patched human carotid. | |
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MedLine Citation:
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PMID: 19828588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The hemodynamic effects of carotid artery patching are not well known. Our objective was to develop a fluid-solid finite element model of the endarterectomized and patched carotid artery. METHODS: Hyperelastic materials parameters were determined from studies of 8 cadaveric carotids. Blood flow characteristics were based on intraoperative data from a patient undergoing endarterectomy. Wall shear stress, cyclic strain and effective stress were computed as hemodynamic parameters with known association with endothelial injury, neointimal hyperplasia and atherogenesis. RESULTS: Low wall shear stress, high cyclic strain and high effective stress were identified diffusely in the carotid bulb, at the margins around the patch and in the flow divider. CONCLUSION: Endarterectomy and polytetrafluoroethylene patching produce considerable abnormalities in the hemodynamics of the repaired carotid. Advanced mechanical modeling can be used to evaluate different carotid revascularization approaches to obtain optimized biomechanical and hemodynamic results for the care of patients with carotid bifurcation disease. |
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Authors:
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Alexey V Kamenskiy; Iraklis I Pipinos; Anastasia S Desyatova; Yuriy E Salkovskiy; Leonid Yu Kossovich; Irina V Kirillova; Leo A Bockeria; Konstantin M Morozov; Vasiliy O Polyaev; Thomas G Lynch; Yuris A Dzenis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-10-14 |
Journal Detail:
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Title: Vascular and endovascular surgery Volume: 43 ISSN: 1938-9116 ISO Abbreviation: Vasc Endovascular Surg Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-31 Completed Date: 2010-03-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136421 Medline TA: Vasc Endovascular Surg Country: United States |
Other Details:
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Languages: eng Pagination: 533-41 Citation Subset: IM |
Affiliation:
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Department of Engineering Mechanics, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Biomechanics Blood Flow Velocity Cadaver Carotid Arteries / physiopathology, radiography, surgery*, ultrasonography Carotid Stenosis / physiopathology, radiography, surgery*, ultrasonography Elasticity Endarterectomy, Carotid* / instrumentation Female Finite Element Analysis* Hemodynamics* Humans Male Middle Aged Models, Cardiovascular* Polytetrafluoroethylene Regional Blood Flow Stress, Mechanical Tomography, X-Ray Computed Ultrasonography, Doppler, Duplex |
| Grant Support | |
ID/Acronym/Agency:
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1K08 HL079967-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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9002-84-0/Polytetrafluoroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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