| Fingolimod treatment in multiple sclerosis leads to increased macular volume. | |
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MedLine Citation:
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PMID: 23223539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether fingolimod, an oral sphingosine-1-phosphate receptor modulator approved for treatment of multiple sclerosis (MS), generally leads to increased retinal tissue volume. METHODS: In this longitudinal observational study, we compared changes in macular volume on spectral-domain optical coherence tomography (OCT) between consecutive patients with MS who initiated fingolimod and a matched reference cohort of patients with MS never exposed to the drug. The primary reference cohort was matched based on time interval between OCT examinations. A secondary reference cohort was matched based on age and disease duration. Change in macular volume within each group was analyzed using the paired t test. Change in macular volume between groups was examined using multiple linear regression. RESULTS: Macular volume increased by a mean of 0.025 mm3 (95% confidence interval [CI] +0.017 to +0.033, p < 0.001) in the 30 patients with MS who initiated fingolimod over a mean follow-up time of 5 months (SD 3). Macular volume did not significantly change over a mean follow-up time of 6 months (SD 4) in a comparison group of 30 patients with MS never treated with fingolimod (mean change of -0.003 mm3, 95% CI -0.009 to +0.004, p = 0.47). Overall, 74% of eyes in the fingolimod-treated group exhibited an increase in macular volume vs. 37% of eyes in the comparison group. CONCLUSION: Initiation of fingolimod in MS is associated with a modest, relatively rapid increase in macular volume. |
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Authors:
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Rachel Nolan; Jeffrey M Gelfand; Ari J Green |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-12-05 |
Journal Detail:
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Title: Neurology Volume: 80 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-08 Completed Date: 2013-03-01 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 139-44 Citation Subset: AIM; IM |
Affiliation:
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Multiple Sclerosis Center, UCSF Department of Neurology, San Francisco, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Immunosuppressive Agents / therapeutic use* Linear Models Longitudinal Studies Macula Lutea / pathology* Male Multiple Sclerosis / drug therapy*, pathology Propylene Glycols / therapeutic use* Receptors, Lysosphingolipid / antagonists & inhibitors Retinal Neurons / pathology Sphingosine / analogs & derivatives*, therapeutic use Tomography, Optical Coherence |
| Grant Support | |
ID/Acronym/Agency:
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KL2 RR 024130/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 0/Propylene Glycols; 0/Receptors, Lysosphingolipid; 123-78-4/Sphingosine; 3QN8BYN5QF/fingolimod |
| Comments/Corrections | |
Comment In:
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Neurology. 2013 Jan 8;80(2):128-9
[PMID:
23223537
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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