Document Detail

Fingerprint and high-wavenumber Raman spectroscopy in a human-swine coronary xenograft in vivo.
MedLine Citation:
PMID:  19021305     Owner:  NLM     Status:  MEDLINE    
Intracoronary Raman spectroscopy could open new avenues for the study and management of coronary artery disease due to its potential to measure the chemical and molecular composition of coronary atherosclerotic lesions. We have fabricated and tested a 1.5-mm-diameter (4.5 Fr) Raman catheter capable of collecting Raman spectra in both the fingerprint (400-1800 cm(-1)) and high-wavenumber (2400-3800 cm(-1)) regions. Spectra were acquired in vivo, using a human-swine xenograft model, in which diseased human coronary arteries are grafted onto a living swine heart, replicating the disease and dynamic environment of the human circulatory system, including pulsatile flow and motion. Results show that distinct spectral differences, corresponding to the morphology and chemical composition of the artery wall, can be identified by intracoronary Raman spectroscopy in vivo.
Alexandra H Chau; Jason T Motz; Joseph A Gardecki; Sergio Waxman; Brett E Bouma; Guillermo J Tearney
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Publication Detail:
Type:  Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  13     ISSN:  1083-3668     ISO Abbreviation:  J Biomed Opt     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-01-08     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  040501     Citation Subset:  IM    
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MeSH Terms
Cardiac Catheterization / instrumentation*
Coronary Artery Bypass*
Coronary Artery Disease / diagnosis*
Disease Models, Animal*
Equipment Design
Equipment Failure Analysis
Optical Fibers*
Grant Support

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