Document Detail

Finger photoplethysmogram pulse amplitude changes induced by flow-mediated dilation.
MedLine Citation:
PMID:  18460764     Owner:  NLM     Status:  MEDLINE    
This study was conducted to investigate the utility and efficacy of finger photoplethysmogram pulse amplitude (PPG-AC) in comparison with the standard Doppler ultrasound in assessing an endothelial function via flow-mediated dilation (FMD). High-resolution B-mode scanning of the right brachial artery (BA) of 31 healthy subjects aged 39.7 +/- 11.3 (range 22-64) years and 52 risk subjects aged 47.7 +/- 10.8 (range 30-65) years were performed before and after 4 min of upper arm occlusion. Concurrent with the ultrasound measurement (where color Doppler imaging was used to enhance arterial boundary detection), PPG signals were recorded from both index fingers for cross evaluation and comparison. Our results show that the finger PPG-AC exhibits a similar response to that of the well-known BA dilation: following the release of pressure (cuff around the BA), the PPG-AC increases abruptly before slowly decreasing toward the baseline. The peak PPG-AC is reached significantly faster than the peak FMD measured by ultrasound among healthy and risk groups (P < 0.001). The proposed technique using a finger photoplethysmogram can be applied in a rapid and non-invasive assessment of peripheral vascular functions as an alternative low-cost and less operator-dependent tool compared to ultrasound.
E Zahedi; R Jaafar; M A Mohd Ali; A L Mohamed; O Maskon
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-07
Journal Detail:
Title:  Physiological measurement     Volume:  29     ISSN:  0967-3334     ISO Abbreviation:  Physiol Meas     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-07     Completed Date:  2008-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306921     Medline TA:  Physiol Meas     Country:  England    
Other Details:
Languages:  eng     Pagination:  625-37     Citation Subset:  IM    
Biomedical Engineering Laboratory, School of Electrical Engineering, Sharif University of Technology, Tehran, Iran.
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MeSH Terms
Blood Flow Velocity / physiology*
Blood Pressure / physiology*
Brachial Artery / physiology*,  ultrasonography
Fingers / blood supply*,  physiology*
Middle Aged
Photoplethysmography / methods*
Reproducibility of Results
Sensitivity and Specificity
Vasodilation / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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