| Fine-tuning of dendritic cell biology by the TNF superfamily. | |
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MedLine Citation:
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PMID: 22487654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Members of the tumour necrosis factor (TNF) superfamily have been implicated in a wide range of biological functions, and their expression by cells of the immune system makes them appealing targets for immunomodulation. One common theme for TNF superfamily members is their coordinated expression at the interface between antigen-specific T cells and antigen-presenting dendritic cells and, by virtue of this expression pattern, TNF superfamily members can shape T cell immune responses. Understanding how to manipulate such functions of the TNF superfamily may allow us to tip the balance between immunity and tolerance in the context of human disease. |
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Authors:
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Leslie Summers deLuca; Jennifer L Gommerman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-04-10 |
Journal Detail:
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Title: Nature reviews. Immunology Volume: 12 ISSN: 1474-1741 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-26 Completed Date: 2012-06-18 Revised Date: 2012-07-16 |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 339-51 Citation Subset: IM |
Affiliation:
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University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dendritic Cells / immunology*, metabolism* Humans Inflammation / immunology Lymphoid Tissue / immunology Neoplasms / drug therapy, immunology Tumor Necrosis Factors / antagonists & inhibitors, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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MOP 67157//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Tumor Necrosis Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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