Document Detail

Fine-tuning of dendritic cell biology by the TNF superfamily.
MedLine Citation:
PMID:  22487654     Owner:  NLM     Status:  MEDLINE    
Members of the tumour necrosis factor (TNF) superfamily have been implicated in a wide range of biological functions, and their expression by cells of the immune system makes them appealing targets for immunomodulation. One common theme for TNF superfamily members is their coordinated expression at the interface between antigen-specific T cells and antigen-presenting dendritic cells and, by virtue of this expression pattern, TNF superfamily members can shape T cell immune responses. Understanding how to manipulate such functions of the TNF superfamily may allow us to tip the balance between immunity and tolerance in the context of human disease.
Leslie Summers deLuca; Jennifer L Gommerman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-10
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  12     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-26     Completed Date:  2012-06-18     Revised Date:  2012-07-16    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  339-51     Citation Subset:  IM    
University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
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MeSH Terms
Dendritic Cells / immunology*,  metabolism*
Inflammation / immunology
Lymphoid Tissue / immunology
Neoplasms / drug therapy,  immunology
Tumor Necrosis Factors / antagonists & inhibitors,  metabolism*
Grant Support
MOP 67157//Canadian Institutes of Health Research
Reg. No./Substance:
0/Tumor Necrosis Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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