Document Detail

Fine structural correlations between the muscle pathology of amyotrophic lateral sclerosis (ALS) patients and experimental Ca-Mg deficient rats.
MedLine Citation:
PMID:  520467     Owner:  NLM     Status:  MEDLINE    
Nonspecific myofibrillar changes such as streaming of the Z-line, formation of rod-like structures, satellitosis, proliferation of sarcolemmal nuclei and papillary projection of the sarcolemma were recognized as a disorganization of the muscle itself. In addition, fine structural pathology in ALS specimens showed characteristically a pig-tail formation - 'Zopfformation' - which has been considered to have a neurogenic origin.
T Kumamoto; C Suematsu; Y Yata; Y Yase
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experientia     Volume:  35     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1979 Dec 
Date Detail:
Created Date:  1980-03-17     Completed Date:  1980-03-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1604-5     Citation Subset:  IM    
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MeSH Terms
Amyotrophic Lateral Sclerosis / pathology*
Calcium / deficiency*
Cell Nucleus / ultrastructure
Disease Models, Animal
Magnesium Deficiency*
Muscles / pathology*,  ultrastructure
Sarcolemma / ultrastructure
Reg. No./Substance:

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