Document Detail

Fine structural changes in dog myocardium exposed to lowered pH in vivo.
MedLine Citation:
PMID:  19649     Owner:  NLM     Status:  MEDLINE    
A surgical preparation that allows chemical alteration of the blood supplied to specific area of the intact heart was used to investigate the effects of lowered tissue pH on the fine structure of myocardial cells. Controlled infusion of isotonic saline acidified with HCl to a pH value between 1.0 and 2.0 produced a lowering of blood pH to values of less than 7.0. This drop in the pH of the perfusing blood resulted in a corresponding decrease in pH of the relevant area of myocardium. When this decrease occurred without a concomitant increase in tissue lactate level, the myocardial cells of the acid-perfused area showed focal glycogen depletion, moderate relaxation of myofibrils and clumping of nuclear chromatin, and mild mitochondrial change, which did not include marked swelling although intramitochondrial electron-dense inclusions were often detectable. When the fall in pH was accompanied by a large increase in lactate concentration, however, the cells showed more severe glycogen depletion and clumping of nuclear chromatin, and mitochondrial change, which did include marked swelling, together with the presence of well developed inclusions.
L C Armiger; R N Seelye; J G Elswijk; V M Carnell; J B Gavin; P B Herdson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory investigation; a journal of technical methods and pathology     Volume:  37     ISSN:  0023-6837     ISO Abbreviation:  Lab. Invest.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376617     Medline TA:  Lab Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  237-42     Citation Subset:  IM    
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MeSH Terms
Chromatin / ultrastructure
Cytoplasmic Granules / ultrastructure
Hydrogen-Ion Concentration
Lactates / metabolism
Mitochondria, Muscle / ultrastructure
Myocardium / metabolism,  ultrastructure*
Myofibrils / ultrastructure
Reg. No./Substance:
0/Chromatin; 0/Lactates; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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