| Fine structural alterations of bovine peripheral pulmonary arteries in hypoxia-induced hypertension. | |
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MedLine Citation:
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PMID: 4357176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cellular alterations of the distal bovine pulmonary arteries in hypoxia-induced pulmonary hypertension were studied. These lesions were related to pulmonary hemodynamic changes and contrasted to the cellular response observed in hyperkinetic pulmonary and systemic hypertension as well as other forms of vascular injury. Medial thickening and mild adventitial proliferation with an absence of intimal proliferative lesions related to a progressive increase in mean pulmonary arterial pressure and pulmonary vascular resistance were observed. Smooth muscle and endothelial cells exhibited distinct degenerative alterations in response to the maintained hypertensive state resulting from the lowered alveolar oxygen tension. |
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Authors:
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R S Jaenke; A F Alexander |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of pathology Volume: 73 ISSN: 0002-9440 ISO Abbreviation: Am. J. Pathol. Publication Date: 1973 Nov |
Date Detail:
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Created Date: 1974-01-31 Completed Date: 1974-01-31 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 377-98 Citation Subset: AIM; IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Altitude Animals Anoxia / complications, pathology* Atmospheric Pressure Blood Pressure Cardiac Output Catheterization Cattle Endoplasmic Reticulum Endothelium / cytology, metabolism Golgi Apparatus Hypertension, Pulmonary / etiology, pathology* Inclusion Bodies Microscopy, Electron Mitochondria, Muscle Muscle, Smooth / pathology Pulmonary Alveoli / blood supply Pulmonary Artery / pathology* Pulmonary Circulation* Vascular Resistance |
| Comments/Corrections | |
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