Document Detail


Fine-scale population structure and the era of next-generation sequencing.
MedLine Citation:
PMID:  20876616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fine-scale population structure characterizes most continents and is especially pronounced in non-cosmopolitan populations. Roughly half of the world's population remains non-cosmopolitan and even populations within cities often assort along ethnic and linguistic categories. Barriers to random mating can be ecologically extreme, such as the Sahara Desert, or cultural, such as the Indian caste system. In either case, subpopulations accumulate genetic differences if the barrier is maintained over multiple generations. Genome-wide polymorphism data, initially with only a few hundred autosomal microsatellites, have clearly established differences in allele frequency not only among continental regions, but also within continents and within countries. We review recent evidence from the analysis of genome-wide polymorphism data for genetic boundaries delineating human population structure and the main demographic and genomic processes shaping variation, and discuss the implications of population structure for the distribution and discovery of disease-causing genetic variants, in the light of the imminent availability of sequencing data for a multitude of diverse human genomes.
Authors:
Brenna M Henn; Simon Gravel; Andres Moreno-Estrada; Suehelay Acevedo-Acevedo; Carlos D Bustamante
Related Documents :
24571236 - On the evolution of migration in heterogeneous environments.
6240576 - Genetic study of high longevity index populations.
24604426 - Mutations in the hfe gene and sporadic amyotrophic lateral sclerosis risk: a meta-analy...
15829726 - Single-locus gametophytic incompatibility in autotetraploids.
16193886 - Apo e in multiple sclerosis and optic neuritis: the apo e-epsilon4 allele is associated...
24782086 - Genetic diversity of the chinese traditional herb blumea balsamifera (asteraceae) based...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-09-28
Journal Detail:
Title:  Human molecular genetics     Volume:  19     ISSN:  1460-2083     ISO Abbreviation:  Hum. Mol. Genet.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-13     Completed Date:  2011-01-24     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9208958     Medline TA:  Hum Mol Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  R221-6     Citation Subset:  IM    
Affiliation:
Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Genetic Variation / genetics
Genome, Human / genetics
High-Throughput Nucleotide Sequencing / methods*
Humans
Polymorphism, Genetic / genetics
Grant Support
ID/Acronym/Agency:
1R01GM083606/GM/NIGMS NIH HHS; 1RC2HL102926/HL/NHLBI NIH HHS; 2R01HG003229/HG/NHGRI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns defi...
Next Document:  Evolutionary history of regulatory variation in human populations.