Document Detail

Fine-resolution physical mapping of genomic diversity in Candida albicans.
MedLine Citation:
PMID:  11116083     Owner:  NLM     Status:  MEDLINE    
It has been suggested that Candida albicans, a diploid asexual fungus, achieves genetic diversity by genomic rearrangement. This important human pathogen may provide a system in which to analyze alternate routes to genomic diversity. C. albicans has a highly variable karyotype; its chromosomes contain a middle repeated DNA sequence called the Major Repeat Sequence (MRS), composed of subrepeats HOK, RPS, and RB2. RPS is tandemly repeated while the other subrepeats occur once in each MRS. Chromosome 7, the smallest of the eight chromosomes, has been previously mapped. The complete physical map of this chromosome was used to analyze chromosome 7 diversity in six strains, including two well-characterized laboratory strains (1006 and WO-1) and four clinical ones. We found four types of events to explain the genomic diversity: 1) Chromosome length polymorphism (CLP) results from expansion and contraction of the RPS; 2) reciprocal translocation occurs at the MRS loci; 3) chromosomal deletion; and (4) trisomy of individual chromosomes. These four phenomena play an important role in generating genomic diversity in C. albicans.
H Chibana; J L Beckerman; P T Magee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genome research     Volume:  10     ISSN:  1088-9051     ISO Abbreviation:  Genome Res.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-27     Completed Date:  2001-02-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9518021     Medline TA:  Genome Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1865-77     Citation Subset:  IM    
Department of Genetics, Cell Biology, and Development, University of Minnesota, St. Paul, Minnesota 55108, USA.
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MeSH Terms
Candida albicans / genetics*
Chromosomes, Fungal / genetics,  metabolism
DNA Fragmentation / genetics
Deoxyribonucleases, Type II Site-Specific / metabolism
Genetic Variation
Genome, Fungal*
Nucleic Acid Hybridization
Physical Chromosome Mapping / methods*
Tandem Repeat Sequences / genetics
Translocation, Genetic / genetics
Grant Support
Reg. No./Substance:
EC 3.1.21.-/endodeoxyribonuclease SfiI; EC, Type II Site-Specific

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