Document Detail

Fine particulate matter and wheezing illnesses in the first year of life.
MedLine Citation:
PMID:  15475719     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recent evidence implicates fine particulate matter (PM2.5), principally from vehicular exhaust, as a major cause of increased mortality and morbidity. However, there are limited data on the impact of PM2.5 on infant respiratory illnesses. METHODS: We conducted a cohort study of 504 infants recruited at 4 months of age from primary health care units in southeastern Santiago, Chile. Project physicians followed infants through the first year of life via monthly check-ups and by appointments on demand. We obtained data for fine particulate matter, sulfur dioxide (SO2), and nitrogen dioxide (NO2) from the governmental monitoring network. RESULTS: The most frequent diagnosis during follow-up was wheezing bronchitis, occurring 19.5 times per 100 infants per month. After adjusting for sex, socioeconomic level, family history of asthma, minimum temperature, and number of older siblings, we found that an increase of 10 microg/m of PM2.5 24-hour average was related to a 5% increase (95% confidence interval 0-9%) in the risk for wheezing bronchitis (1-day lag). This association was present for different lags, with a maximum observed for a 9-day lag (9%; 6-12%). No consistent association was detected with NO2 or SO2 ambient levels. Lower socioeconomic status and having older siblings were also associated with the risk of wheezing bronchitis. The association of PM2.5 and wheezing bronchitis was stronger among infants with a family history of asthma than among infants without. CONCLUSIONS: Air pollution in the form of fine particulates, mostly from vehicular exhaust, may adversely affect infants' respiratory health with potential for chronic effects later in life.
Paulina Pino; Tomas Walter; Manuel Oyarzun; Rodrigo Villegas; Isabelle Romieu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  15     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-11     Completed Date:  2005-04-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  702-8     Citation Subset:  IM    
Facultad de Medicina, Universidad de Chile, Santiago, Chile.
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MeSH Terms
Air Pollutants / analysis
Air Pollution, Indoor / analysis
Bronchitis / epidemiology,  etiology*
Chile / epidemiology
Cohort Studies
Environmental Exposure / adverse effects*
Multivariate Analysis
Particle Size
Respiratory Sounds / etiology*
Risk Factors
Socioeconomic Factors
Tobacco Smoke Pollution / adverse effects*,  analysis
Grant Support
Reg. No./Substance:
0/Air Pollutants; 0/Tobacco Smoke Pollution

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