Document Detail

Fine-needle cytology and flow cytometry assessment of reactive and lymphoproliferative processes of the breast.
MedLine Citation:
PMID:  22378074     Owner:  NLM     Status:  In-Data-Review    
Objective: The breast may be affected by reactive and lymphoproliferative processes such as primary (PBL) or secondary (SBL) lymphoma, reactive intramammary lymph nodes and sclerosing lobulitis; imaging may be not specific and surgical treatment not indicated. We report an experience with fine-needle cytology (FNAC) combined with flow cytometry (FC) and immunocytochemistry (ICC) in the diagnosis of these processes. Study Design: Thirty-seven cases comprising intramammary lymph nodes (n = 15), sclerosing lobulitis (n = 2), PBL (n = 11) and SBL (n = 9) are reported. FNAC was used to prepare traditional smears, conventional ICC or FC. Cytological diagnoses were compared to the imaging data, checked by histology or follow-up and statistically evaluated. Results: Imaging was not conclusive in most PBL, SBL, sclerosing lobulitis and some intramammary lymph nodes. FNAC combined with FC and ICC provided a definitive diagnosis of intramammary lymph node, sclerosing lobulitis, PBL and SBL in 18 cases with indication of the specific subtype in 10 cases. Statistical analysis showed 90% sensitivity, 100% specificity, 100% positive predictive value and 89% negative predictive value. Conclusions: FNAC combined with FC and ICC is a helpful procedure for the diagnosis of reactive and lymphoproliferative processes of the breast. It may prevent unnecessary biopsy and speed up therapeutic procedures.
Elena Vigliar; Immacolata Cozzolino; Laura Virginia Sosa Fernandez; Leda Di Pietto; Albina Riccardi; Marco Picardi; Fabrizio Pane; Antonio Vetrani; Giancarlo Troncone; Pio Zeppa
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Publication Detail:
Type:  Journal Article     Date:  2012-02-17
Journal Detail:
Title:  Acta cytologica     Volume:  56     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  130-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Dipartimenti di Scienze Biomorfologiche e Funzionali, Facoltà di Medicina e Chirurgia, Università di Napoli 'Federico II', Napoli, Italia.
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