Document Detail


Fine-needle cytology and flow cytometry assessment of reactive and lymphoproliferative processes of the breast.
MedLine Citation:
PMID:  22378074     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective: The breast may be affected by reactive and lymphoproliferative processes such as primary (PBL) or secondary (SBL) lymphoma, reactive intramammary lymph nodes and sclerosing lobulitis; imaging may be not specific and surgical treatment not indicated. We report an experience with fine-needle cytology (FNAC) combined with flow cytometry (FC) and immunocytochemistry (ICC) in the diagnosis of these processes. Study Design: Thirty-seven cases comprising intramammary lymph nodes (n = 15), sclerosing lobulitis (n = 2), PBL (n = 11) and SBL (n = 9) are reported. FNAC was used to prepare traditional smears, conventional ICC or FC. Cytological diagnoses were compared to the imaging data, checked by histology or follow-up and statistically evaluated. Results: Imaging was not conclusive in most PBL, SBL, sclerosing lobulitis and some intramammary lymph nodes. FNAC combined with FC and ICC provided a definitive diagnosis of intramammary lymph node, sclerosing lobulitis, PBL and SBL in 18 cases with indication of the specific subtype in 10 cases. Statistical analysis showed 90% sensitivity, 100% specificity, 100% positive predictive value and 89% negative predictive value. Conclusions: FNAC combined with FC and ICC is a helpful procedure for the diagnosis of reactive and lymphoproliferative processes of the breast. It may prevent unnecessary biopsy and speed up therapeutic procedures.
Authors:
Elena Vigliar; Immacolata Cozzolino; Laura Virginia Sosa Fernandez; Leda Di Pietto; Albina Riccardi; Marco Picardi; Fabrizio Pane; Antonio Vetrani; Giancarlo Troncone; Pio Zeppa
Related Documents :
12632534 - Concomitant hepatocellular adenoma and adenomatous hyperplasia in a patient without cir...
856684 - Contribution to the pathology of strobilocercosis (strobilocercus fasciolaris) in the l...
16154814 - Mri in detection of hepatocellular carcinoma (hcc).
8661554 - Peribiliary cysts in cirrhotic liver: observation on computed tomography.
20211664 - Evaluation of the mtt lymphocyte proliferation assay for the diagnosis of neurocysticer...
16220774 - Fibrolamellar hepatocellular carcinoma arising in a background of focal nodular hyperpl...
Publication Detail:
Type:  Journal Article     Date:  2012-02-17
Journal Detail:
Title:  Acta cytologica     Volume:  56     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  130-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Dipartimenti di Scienze Biomorfologiche e Funzionali, Facoltà di Medicina e Chirurgia, Università di Napoli 'Federico II', Napoli, Italia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reclassifying Formerly Indeterminate Thyroid FNAs Using the Bethesda System Reduces the Number of In...
Next Document:  The Role of Axillary Lymph Node Fine Needle Aspiration in Breast Cancer Staging prior to Chemotherap...