Document Detail

Fine needle aspiration cytology of primary thyroid paraganglioma. Report of a case with cytologic, histologic and immunohistochemical features and differential diagnostic considerations.
MedLine Citation:
PMID:  12462095     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Thyroid paraganglioma is a rare tumor and can cause diagnostic difficulties when using fine needle aspiration cytology (FNAC), especially when associated with some cytologic atypia. This case report appears to be the first on FNAC of primary thyroid paraganglioma. CASE: FNAC of a thyroid nodule situated in the right lobe was performed on a 46-year-old female. FNAC showed single cells and loose clusters of large, oval cells with round to oval nuclei, evenly dispersed chromatin, focally discrete nucleoli, moderate anisocytosis and anisonucleosis. A few larger cells showing irregular nuclei and coarser chromatin. The tumorous appearance of the lesion and some cytologic atypia led to a right lobe thyroidectomy, revealing a primary thyroid paraganglioma associated with capsular invasion; slight, focal cytologic atypia; and no vascular invasion. CONCLUSION: The atypia probably originated in the area of capsular invasion. To avoid misdiagnosing these tumors as malignancies, paraganglioma should be added to the differential diagnosis list when dealing with thyroid FNAC showing some atypia.
Aleksandar Vodovnik
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  46     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2002 Nov-Dec
Date Detail:
Created Date:  2002-12-03     Completed Date:  2002-12-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1133-7     Citation Subset:  IM    
Laboratory for Clinical Pathology and Cytology, Gävle-Sandviken County Hospital, Center for Research and Development, Uppsala University-Gävleborg, Gävle, Sweden.
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MeSH Terms
Biopsy, Needle
Diagnosis, Differential
Middle Aged
Paraganglioma / pathology*
Thyroid Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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