Document Detail

Fine-needle aspiration cytology in a regional head and neck cancer center: comparison with a systematic review and meta-analysis.
MedLine Citation:
PMID:  18528906     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Fine-needle aspiration cytology (FNAC) is used to diagnose masses presenting in the head and neck region. No systematic review of FNAC in this group has yet been performed. METHODS: A systematic review of the published literature and meta-analysis of data extracted from the included studies were compared with a 10-year review of head and neck FNAC from our institution. RESULTS: Systematic review identified 30 studies; 3459 FNAC aspirates from all head and neck sites were included. Overall results were as follows: sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) were 89.6%, 96.5%, 93.1%, 96.2%, and 90.3%, respectively. Two thousand seven hundred two head and neck aspirates were included in our institutional review. Sensitivity, specificity, PPV, NPV, and accuracy were 89.5%, 98.5%, 97.3%, 94.0%, and 95.1%, respectively. CONCLUSION: Meta-analysis and comparative systematic review confirm that FNAC is highly effective in the diagnosis of head and neck masses, with some limitations.
Sankalap Tandon; Riad Shahab; James I Benton; Samit K Ghosh; Jonathan Sheard; Terry M Jones
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  Head & neck     Volume:  30     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-22     Completed Date:  2008-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1246-52     Citation Subset:  IM    
Department of Otolaryngology-Head and Neck Surgery, Aintree University Hospitals NHS Foundation Trust, Lower Lane, Liverpool L97AL, United Kingdom.
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MeSH Terms
Biopsy, Fine-Needle / methods*
Combined Modality Therapy
Head and Neck Neoplasms / mortality*,  pathology*,  therapy
Neoplasm Invasiveness / pathology*
Neoplasm Recurrence, Local / mortality,  pathology*
Neoplasm Staging
Risk Assessment
Sensitivity and Specificity
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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