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Fine needle aspiration cytology as the primary diagnostic tool in thyroid enlargement.
MedLine Citation:
PMID:  22470244     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In the preoperative decision-making of the thyroid swellings, fine needle aspiration cytology (FNAC) is becoming an ever more vital tool.
OBJECTIVES: To compare the advantage of preoperative FNAC of thyroid swellings with postoperative histopathology to reach a consensus protocol as a simple procedure for diagnosis and optimal management of thyroid swellings.
MATERIALS AND METHODS: A prospective study of preoperative FNAC was carried out on 178 incidental thyroid swellings attending a tertiary care centre in Kishanganj, Bihar. Evidence-based surgical interventions were done, irrespective of FNAC findings and diagnosis was confirmed by histopathological examination (HPE) postoperatively in all the cases.
RESULTS: In the FNAC, preponderance of the cases (75.84%) was colloid goitre followed by granulomatous thyroiditis; follicular carcinoma was noted in 7.30 percent and anaplastic carcinoma in 3.37 percent of cases. Histopathological examination showed colloid goitre predominantly (76.97%), followed by follicular carcinoma (8.99%). The overall prevalence of malignancy was 11.24 percent diagnosed by HPE and 9.55 percent by FNAC. In our FNAC series sensitivity of was 90 percent while specificity was 100 percent; accuracy was 98.88 percent. Predictive value of a positive test and negative tests was 100 percent and 98.75 percent respectively.
CONCLUSION: The study highlights that FNAC should be treated as a first-line diagnostic test for thyroid swellings to guide the management though this is not a substitute for HPE as a need to improve primary healthcare in India.
Authors:
Arup Sengupta; Ranabir Pal; Sumit Kar; Forhad Akhtar Zaman; Subhabrata Sengupta; Shrayan Pal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of natural science, biology, and medicine     Volume:  2     ISSN:  2229-7707     ISO Abbreviation:  J Nat Sci Biol Med     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2012-04-03     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101571070     Medline TA:  J Nat Sci Biol Med     Country:  India    
Other Details:
Languages:  eng     Pagination:  113-8     Citation Subset:  -    
Affiliation:
Department of Otorhinolaryngology, M.G.M. Medical College, Kisanganj, Bihar, India.
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