Document Detail

Fine needle aspiration biopsy of the thyroid. Differential diagnosis by videoplan image analysis.
MedLine Citation:
PMID:  6760645     Owner:  NLM     Status:  MEDLINE    
Fine needle aspiration biopsy of cold thyroid nodules has become increasingly popular in determining neoplastic versus nonneoplastic conditions. The differential diagnosis between follicular adenoma and low-grade follicular carcinoma has not been consistently attainable, however; adenomatous goiter also may present problems in diagnosis, while papillary carcinoma seldom proves to be a difficult diagnosis. Image analysis, utilizing the Videoplan image analysis system, was performed on fine needle aspiration biopsy smears from these four types of nodules. The nuclear area, maximum diameter, minimal diameter and approximation to a circle were determined for 25 randomly selected cells with intact nuclei in each smear. These values were calculated with a range and standard deviation and were graphed for each parameter by case category. Cytoplasmic measurements could not be performed due to the absence of definite cytoplasmic boundaries. There was no significant difference in mean nuclear area between follicular adenoma, follicular carcinoma and adenomatous goiter. Papillary carcinoma was the only lesion to show any difference with this single parameter. The mean of maximum and minimum diameter and approximation to a circle were similar for all the types of thyroid masses examined in this study. The Videoplan image analysis system provided an efficient and accurate means of obtaining the nuclear measurements and calculating the statistics. These data illustrate that a differential diagnosis between follicular adenoma, follicular carcinoma and adenomatous goiter, while difficult by light microscopy, is not aided by image analysis of individual cell nuclei.
J B Luck; V R Mumaw; W J Frable
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  26     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    1982 Nov-Dec
Date Detail:
Created Date:  1983-03-24     Completed Date:  1983-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  793-6     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / diagnosis
Adenoma / diagnosis
Biopsy, Needle
Carcinoma, Papillary / diagnosis
Cell Nucleus / ultrastructure
Cytological Techniques
Diagnosis, Differential
Goiter / diagnosis*
Thyroid Diseases / diagnosis*,  pathology
Thyroid Neoplasms / diagnosis*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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