| Fine mapping of the region including hypogonadism (hgn) locus on rat chromosome 10. | |
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MedLine Citation:
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PMID: 15472484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypogonadic rat (hgn/hgn) shows male sterility, reduced female fertility, and renal hypoplasia, controlled by a single recessive gene located on rat chromosome 10. We developed a fine map around the hgn locus using 565 rat backcross progeny and a Rat/Hamster radiation hybrid panel. The hgn locus was linked to Aldoc (aldolase c) and whn (winged helix of nude), and located in a 0.34-cM region between D10Rat30 and D10Rat68. The distance of the region was approximately 840-kb on rat physical map. Neither loci responsible for male sterility nor renal hypoplasia has been mapped on the homologous regions of mouse chromosome 11 and human chromosome 17. Identification of the gene responsible for the hgn mutation would provide important information on urogenital development. |
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Authors:
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Hiroetsu Suzuki; Eijiro Nakamiya; Kumi Daigo; Kenichi Saito; Katsushi Suzuki |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 66 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-10-08 Completed Date: 2005-01-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1151-4 Citation Subset: IM |
Affiliation:
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Department of Veterinary Physiology, Nippon Veterinary and Animal Science University, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromosome Mapping* Crosses, Genetic Genes, Recessive / genetics Hypogonadism / genetics*, pathology* Male Organ Size / genetics* Rats / genetics* |
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