Document Detail


Fine mapping of porcine SSC14 QTL and SCD gene effects on fatty acid composition and melting point of fat in a Duroc purebred population.
MedLine Citation:
PMID:  22404360     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The stearoyl-CoA desaturase (delta-9-desaturase; SCD) gene is a candidate gene for fatty acid composition. It is located on pig SSC14 in a region where quantitative trait loci (QTL) for fatty acid composition were previously detected in a Duroc purebred population. The objective of the present study was to fine map the QTL, to identify polymorphisms of the pig SCD gene and to examine the effects of SCD polymorphisms on fatty acid composition and melting point of fat in the population. The pigs were examined for fatty acid composition and melting point of inner and outer subcutaneous fat and inter- and intramuscular fat; the number of pigs examined was 479-521. Two SNPs (g.-353C>T and g.-233T>C) were identified in the promoter region of the SCD gene and were completely linked in the pigs from the base generation. In all pigs, 19 microsatellite markers and SCD haplotypes were then genotyped. Different statistical models were applied to evaluate the effects of QTL and the possible causality of the SCD gene variants with respect to the QTL. The results show that all significant QTL for C14:0, C18:0, C18:1 and melting point of fat were detected in the same region, located near the SCD gene. The results also show a significant association between SCD haplotypes and fatty acid composition and fat melting point in this population. These results indicate that the haplotype of the SCD gene has a strong effect on fatty acid composition and melting point of fat.
Authors:
Y Uemoto; H Nakano; T Kikuchi; S Sato; M Ishida; T Shibata; H Kadowaki; E Kobayashi; K Suzuki
Publication Detail:
Type:  Journal Article     Date:  2011-08-01
Journal Detail:
Title:  Animal genetics     Volume:  43     ISSN:  1365-2052     ISO Abbreviation:  Anim. Genet.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605704     Medline TA:  Anim Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  225-8     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors, Animal Genetics © 2011 Stichting International Foundation for Animal Genetics.
Affiliation:
National Livestock Breeding Center, Nishigo, Fukushima 961-8511, Japan Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 981-8555, Japan Miyagi University, Sendai, Miyagi 982-0215, Japan Miyagi Prefecture Animal Industry Experiment Station, Ohsaki, Miyagi 989-6445, Japan.
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