Document Detail

Fine mapping of the muscular dystrophy (AM) gene on chicken chromosome 2q.
MedLine Citation:
PMID:  15373744     Owner:  NLM     Status:  MEDLINE    
Our previous studies revealed that the genetic locus for chicken muscular dystrophy of abnormal muscle (AM) mapped to chromosome 2q, and that the region showed conserved synteny with human chromosome 8q11-24.3. In the current study, we mapped the chicken orthologues of genes from human chromosome 8q11-24 in order to identify the responsible gene. Polymorphisms in the chicken orthologues were identified in the parents of the resource family. Twenty-three genes and expressed sequence tags (ESTs) were mapped to chicken chromosome 2 by linkage analysis. The detailed comparative map shows a high conservation of synteny between chicken chromosome 2q and human chromosome 8q. The AM locus was mapped between [inositol(myo)-1(or4)-monophosphatase 1] (IMPA1) gene and [core-binding factor, runt domain, alpha-subunit 2; translocated to 1; cyclin D-related] (CBFA2T1) gene. The genes located between IMPA1 and CBFA2T1 are the most likely candidates for chicken muscular dystrophy.
K Yoshizawa; K Inaba; H Mannen; T Kikuchi; M Mizutani; S Tsuji
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Animal genetics     Volume:  35     ISSN:  0268-9146     ISO Abbreviation:  Anim. Genet.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-17     Completed Date:  2004-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8605704     Medline TA:  Anim Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  397-400     Citation Subset:  IM    
Graduate School of Science and Technology, Kobe University, 1-1 Rokkoudai-cho, Nada-ku, 657-8501, Japan.
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MeSH Terms
Chickens / genetics*
Chromosome Mapping*
Chromosomes, Human, Pair 8 / genetics*
DNA Primers
Expressed Sequence Tags*
Muscular Dystrophy, Animal / genetics*
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Synteny / genetics
Reg. No./Substance:
0/DNA Primers

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