Document Detail

Findings in routine laboratory examination in progressive myoclonus epilepsy.
MedLine Citation:
PMID:  804227     Owner:  NLM     Status:  MEDLINE    
Thirty-one patients suffering from progressive myoclonus epilepsy, (also called Unverricht-Lundborg's disease) without Lafora bodies, were examined to check the findings reported in literature and to chart out the main abnormalities in routine laboratory findings. Many alterations could be pointed out, but a high proportion of them were due to factors which are secondary to the syndrome of progressive myoclonus epilepsy: continuous anticonvulsive medication; immobilization; frequent infections; and the patient's poor nutritional condition. The most remarkable finding, and the only one which supported the abnormality reported earlier, was the raised excretion of indican which could not be explained by fermentation in the bowels. The urinary 5-hydroxyindoleacetic acid excretion was a little low, but still within the normal range. The tryptophan and 5-hydroxytryptamine metabolism deserves further investigation in attempting to discover the aetiology of progressive myoclonus epilepsy.
M Koskiniemi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  51     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-05-27     Completed Date:  1975-05-27     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  12-20     Citation Subset:  IM    
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MeSH Terms
Age Factors
Blood Glucose
Blood Proteins
Cerebrospinal Fluid Proteins
Copper / blood
Creatinine / blood
Disability Evaluation
Epilepsy* / blood,  drug therapy
Hydroxyindoleacetic Acid / urine
Indican / urine
Phenytoin / therapeutic use
Reg. No./Substance:
0/Blood Glucose; 0/Blood Proteins; 0/Cerebrospinal Fluid Proteins; 487-94-5/Indican; 54-16-0/Hydroxyindoleacetic Acid; 57-41-0/Phenytoin; 60-27-5/Creatinine; 7440-50-8/Copper

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