Document Detail

Findings in detection of herpesviridae by polymerase chain reaction and intraocular antibody production in a case series of anterior uveitis.
MedLine Citation:
PMID:  23323583     Owner:  NLM     Status:  In-Data-Review    
Purpose: To target the use of two biologic tests in the diagnostic of viral Herpesviridae anterior uveitis (AC) by the consideration of clinical behavior and delay of intraocular sampling. Methods: Aqueous humor samples were collected from 42 patients suspected of having AU of infectious origin at presentation. The diagnosis of infectious uveitis was confirmed by quantification of antibodies with the Goldmann-Witmer coefficient (GWC) and/or detection of Herpesviridae genomes with PCR. The data were compared with data of 16 uveitis control samples used to calculate the specificity of the tests. Results: Sixteen out of 42 eyes (38%) had a final diagnosis of anterior segment infectious uveitis of viral origin (Herpesviridae) confirmed by PCR positive result (5/14 eyes; 14 of the 16 eyes were tested by PCR) and/or specific intraocular antibody synthesis (14/16 eyes). Conclusions: While the GWC is progressively less often performed, these findings suggest that it still has a role in AU suspected of herpesvirus etiology.
Marie-Hélène Errera; Pablo Goldschmidt; Laurence Batellier; Sandrine Degorge; Emmanuel Héron; Laurent Laroche; José-Alain Sahel; Mark Westcott; Christine Chaumeil
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  21     ISSN:  1744-5078     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  England    
Other Details:
Languages:  eng     Pagination:  46-53     Citation Subset:  IM    
Service d'Ophtalmologie IV, Centre National d'Ophtalmologie des Quinze-Vingts , Paris , France.
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