| Finding of vascular amyloid TTR in inferior nasal concha in a patient with FAP TTRVal30Met. | |
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MedLine Citation:
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PMID: 19065300 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the case of a female patient with familial amyloid polyneuropathy (FAP) who demonstrated TTR amyloid deposition in the inferior nasal conchal vessels. To our knowledge this location has not been described previously in FAP; in addition, it was detected in a patient who had undergone successful liver transplantation (LTX) 4 years earlier. The amyloid deposition was found incidentally during examination of a right nasal obstruction caused by a nonspecific inflammatory polyp. Small focal deposits of amyloid TTR were observed on deep thick walled vessels, contrasting with the massive deposition reported in neoformed vessels in amyloidomas. This amyloid was clearly deposited between the onset of FAP and LTX and had probably decreased since the graft. If amyloid deposition is frequent in inferior nasal concha in FAP, this location could be a suitable biopsy site. |
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Authors:
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Miguel Munar-Ques; Jacinto Martinez-Nadal; Jose Juan Torres-Rovira; Manel Sole; Jose Maria Zabay-Becerril; Juana Maria Mulet-Ferrer |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis Volume: 15 ISSN: 1744-2818 ISO Abbreviation: Amyloid Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-09 Completed Date: 2009-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433802 Medline TA: Amyloid Country: United States |
Other Details:
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Languages: eng Pagination: 272-4 Citation Subset: IM |
Affiliation:
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Grupo de Estudio de la Paf, Majorca, Spain. munar-ques@ogm.jazztel.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Substitution Amyloid / genetics, metabolism* Amyloid Neuropathies, Familial / genetics*, metabolism*, pathology, surgery Female Heterozygote Humans Liver Transplantation Middle Aged Nasal Cavity / blood supply, metabolism, pathology Nasal Polyps / metabolism*, pathology Prealbumin / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amyloid; 0/Prealbumin; 87090-18-4/amyloid prealbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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