Document Detail


Finding the end: recruitment of telomerase to telomeres.
MedLine Citation:
PMID:  23299958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit repair by telomere-associated proteins, which in mammals form the shelterin complex. Replicative polymerases are unable to synthesize DNA at the extreme ends of chromosomes, but in unicellular eukaryotes such as yeast and in mammalian germ cells and stem cells, telomere length is maintained by a ribonucleoprotein enzyme known as telomerase. Recent work has provided insights into the mechanisms of telomerase recruitment to telomeres, highlighting the contribution of telomere-associated proteins, including TPP1 in humans, Ccq1 in Schizosaccharomyces pombe and Cdc13 and Ku70-Ku80 in Saccharomyces cerevisiae.
Authors:
Jayakrishnan Nandakumar; Thomas R Cech
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-09
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  14     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-23     Completed Date:  2013-03-21     Revised Date:  2013-12-09    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  69-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosomes / chemistry*,  metabolism
Humans
Models, Biological
Models, Molecular
Protein Binding / physiology
Saccharomyces cerevisiae / genetics,  metabolism
Schizosaccharomyces / genetics,  metabolism
Telomerase / metabolism*
Telomere / chemistry,  genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
K99 CA167644/CA/NCI NIH HHS; K99 CA167644/CA/NCI NIH HHS; R01 GM099705/GM/NIGMS NIH HHS; R01 GM099705/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
EC 2.7.7.49/Telomerase
Comments/Corrections

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