Document Detail

Finasteride treatment of female pattern hair loss.
MedLine Citation:
PMID:  16549704     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the efficacy of oral finasteride therapy associated with an oral contraceptive containing drospirenone and ethinyl estradiol in premenopausal women with female pattern hair loss. SETTING: Outpatient consultation for hair disorders at the Department of Dermatology, University of Bologna. PATIENTS AND INTERVENTION: Thirty-seven women with female pattern hair loss were treated with oral finasteride, 2.5 mg/d, while taking an oral contraceptive containing drospirenone and ethinyl estradiol. Treatment efficacy was evaluated using global photography and the hair density score from videodermoscopy. A self-administered questionnaire was used to assess patient evaluation of treatment effectiveness. RESULTS: At 12-month follow-up, 23 of the 37 patients were rated as improved using global photography (12 were slightly improved, 8 were moderately improved, and 3 were greatly improved). No improvement was recorded in 13 patients. One patient experienced worsening of the condition. There was a statistically significant (P = .002) increase in the hair density score in 12 patients. No adverse reactions to the drug were reported. CONCLUSIONS: Sixty-two percent of the patients demonstrated some improvement of their hair loss with the use of finasteride, 2.5 mg/d, while taking the oral contraceptive. It is unclear whether the success was due to a higher dosage of finasteride (2.5 mg instead of 1 mg) or to its association with the oral contraceptive containing drospirenone, which has an antiandrogenic effect. Further studies are necessary to understand which patterns of female pattern hair loss respond better to this treatment.
Matilde Iorizzo; Colombina Vincenzi; Stylianos Voudouris; Bianca Maria Piraccini; Antonella Tosti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  142     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-21     Completed Date:  2006-04-11     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  298-302     Citation Subset:  AIM; IM    
Department of Dermatology, University of Bologna, Via Massarenti, I-40138 Bologna, Italy.
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MeSH Terms
Administration, Oral
Aldosterone Antagonists / administration & dosage
Alopecia / drug therapy*
Contraceptives, Oral, Combined / administration & dosage
Enzyme Inhibitors / administration & dosage*
Estrogens / administration & dosage
Ethinyl Estradiol / administration & dosage
Finasteride / administration & dosage*
Middle Aged
Testosterone 5-alpha-Reductase / antagonists & inhibitors*
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Contraceptives, Oral, Combined; 0/Enzyme Inhibitors; 0/Estrogens; 57-63-6/Ethinyl Estradiol; 98319-26-7/Finasteride; EC 5-alpha-Reductase
Comment In:
Arch Dermatol. 2006 Mar;142(3):362-4   [PMID:  16549715 ]

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