Document Detail


Finasteride-induced myalgia and HyperCKemia.
MedLine Citation:
PMID:  19169095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Finasteride is an antiandrogen, inhibits type II 5-alpha reductase (enzyme that converts testosterone to more potent form dihydrotestosterone), and is commonly used in the treatment of benign prostatic hyperplasia and male frontal baldness; however, it is not free from side effects, which include sexual dysfunction and, rarely, myopathy. We report a case of finasteride-associated myalgia and hyperCKemia and review similar cases reported in the literature. CASE REPORT: A 30-year-old man who had been taking finasteride 5 mg/d for 10 years to treat frontal baldness developed diffuse muscle aches associated with elevated creatine kinase level to 10,117 IU/L with neither weakness nor pigmenturia. His symptoms resolved and his creatine kinase level dropped down to 256 IU/L 3 weeks after finasteride discontinuation. CONCLUSION: Reversible myalgia associated with significant hyperCKemia is a possible adverse reaction of finasteride therapy.
Authors:
Talal M Al-Harbi; Jennifer Kagan; Mark A Tarnopolsky
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical neuromuscular disease     Volume:  10     ISSN:  1537-1611     ISO Abbreviation:  J Clin Neuromuscul Dis     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887391     Medline TA:  J Clin Neuromuscul Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  76-8     Citation Subset:  IM    
Affiliation:
Neurology Division, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alopecia / drug therapy
Biological Markers / analysis,  blood
Creatine Kinase, MM Form / analysis,  blood*
Enzyme Inhibitors / adverse effects
Finasteride / adverse effects*
Humans
Male
Muscle, Skeletal / drug effects*,  metabolism,  physiopathology
Muscular Diseases / chemically induced*,  metabolism,  physiopathology
Pain / chemically induced*,  metabolism,  physiopathology
Predictive Value of Tests
Testosterone / adverse effects
Up-Regulation / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Enzyme Inhibitors; 58-22-0/Testosterone; 98319-26-7/Finasteride; EC 2.7.3.2/Creatine Kinase, MM Form

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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