| Finasteride-induced myalgia and HyperCKemia. | |
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MedLine Citation:
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PMID: 19169095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Finasteride is an antiandrogen, inhibits type II 5-alpha reductase (enzyme that converts testosterone to more potent form dihydrotestosterone), and is commonly used in the treatment of benign prostatic hyperplasia and male frontal baldness; however, it is not free from side effects, which include sexual dysfunction and, rarely, myopathy. We report a case of finasteride-associated myalgia and hyperCKemia and review similar cases reported in the literature. CASE REPORT: A 30-year-old man who had been taking finasteride 5 mg/d for 10 years to treat frontal baldness developed diffuse muscle aches associated with elevated creatine kinase level to 10,117 IU/L with neither weakness nor pigmenturia. His symptoms resolved and his creatine kinase level dropped down to 256 IU/L 3 weeks after finasteride discontinuation. CONCLUSION: Reversible myalgia associated with significant hyperCKemia is a possible adverse reaction of finasteride therapy. |
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Authors:
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Talal M Al-Harbi; Jennifer Kagan; Mark A Tarnopolsky |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical neuromuscular disease Volume: 10 ISSN: 1537-1611 ISO Abbreviation: J Clin Neuromuscul Dis Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-01-26 Completed Date: 2009-04-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100887391 Medline TA: J Clin Neuromuscul Dis Country: United States |
Other Details:
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Languages: eng Pagination: 76-8 Citation Subset: IM |
Affiliation:
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Neurology Division, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alopecia / drug therapy Biological Markers / analysis, blood Creatine Kinase, MM Form / analysis, blood* Enzyme Inhibitors / adverse effects Finasteride / adverse effects* Humans Male Muscle, Skeletal / drug effects*, metabolism, physiopathology Muscular Diseases / chemically induced*, metabolism, physiopathology Pain / chemically induced*, metabolism, physiopathology Predictive Value of Tests Testosterone / adverse effects Up-Regulation / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Enzyme Inhibitors; 58-22-0/Testosterone; 98319-26-7/Finasteride; EC 2.7.3.2/Creatine Kinase, MM Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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