Document Detail


Final report of the safety assessment of cosmetic ingredients derived from zea mays (corn).
MedLine Citation:
PMID:  21772025     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Many cosmetic ingredients are derived from Zea mays (corn). While safety test data were not available for most ingredients, similarities in preparation and the resulting similar composition allowed extrapolation of safety data to all listed ingredients. Animal studies included acute toxicity, ocular and dermal irritation studies, and dermal sensitization studies. Clinical studies included dermal irritation and sensitization. Case reports were available for the starch as used as a donning agent in medical gloves. Studies of many other endpoints, including reproductive and developmental toxicity, use corn oil as a vehicle control with no reported adverse effects at levels used in cosmetics. While industry should continue limiting ingredient impurities such as pesticide residues before blending into a cosmetic formulation, the CIR Expert Panel determined that corn-derived ingredients are safe for use in cosmetics in the practices of use and concentration described in the assessment.
Authors:
F Alan Andersen; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of toxicology     Volume:  30     ISSN:  1092-874X     ISO Abbreviation:  Int. J. Toxicol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-07-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708436     Medline TA:  Int J Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17S-39S     Citation Subset:  IM    
Affiliation:
Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA. Email: cirinfo@cir-safety.org.
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