Document Detail


Final report on the safety assessment of Corylus Avellana (Hazel) Seed Oil, Corylus Americana (Hazel) Seed Oil, Corylus Avellana (Hazel) Seed Extract, Corylus Americana (Hazel) Seed Extract, Corylus Avellana (Hazel) Leaf Extract, Corylus Americana (Hazel) Leaf Extract, and Corylus Rostrata (Hazel) Leaf Extract.
MedLine Citation:
PMID:  11358108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
These ingredients are all derived from hazelnut trees. The two seed oils are expressed from the nuts of the hazelnut tree of the particular species identified. Most current reported cosmetic uses are of the seed oils. The seed extracts are the extract of the nuts of the identified species tree. There is one current report of use of seed extract in cosmetics. The leaf extracts are the extract from the leaves of the particular species tree. There are no current reports of use of these extracts in cosmetics. Analysis of seed oil from one species identified Oleic Acid, Palmitoleic Acid, Linoleic Acid, Eicosaenoic Acid, Docosenoic Acid, Eicosanoic Acid, Palmitic Acid, Linolenic Acid, Stearic Acid, and Tetraeicosanoic Acid. Little information is available to characterize the extracts, however. The functions of most of these ingredients in cosmetics are not reported. In studies of hazelnuts from Spain and Egypt, aflatoxin was reported as a possible contaminant. Aflatoxins are considered carcinogenic in humans. Virtually no safety test data are available on these ingredients. Negative results in one comedogenicity study using a seed oil are reported. Cross-sensitivity to proteins in peanuts and those in hazelnuts are reported, but the presence or absence of protein in nut extract and plant extract from hazelnut trees is not known. Additional data were provided regarding concentration of use, method of extraction and contaminants, comedogenicity, and ultraviolet (UV) radiation absorption, but these data related to nut oil from only one species, and were not overall sufficient to resolve questions about irritation, sensitization, and photosensitization. Because of the absence of data, it is concluded that the available data are insufficient to support the safety of these ingredients in cosmetic products. Because of the limited information that characterizes any of these oils or extracts, data are needed on each (except that items 1, 2, and 3 below are not needed for Hazel [Corylus Avellana] Nut Oil). The additonal data needs include: (1) current concentration of use; (2) method of extraction/manufacture and quality control (i.e., chemical analyses); (3) contaminants and methods of extraction (especially pesticides and heavy metals); (4) dermal irritation and sensitization; (5) UV absorption; if there is significant absorption, then a photosensitization study will be needed; (6) 28-day dermal toxicity; (7) reproductive and developmental toxicity; and (8) two genotoxicity assays, one in a mammalian system; if positive, then a 2-year dermal carcinogenesis study using National Toxicology Program (NTP) methods may be needed.
Authors:
N Madhaven
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of toxicology     Volume:  20 Suppl 1     ISSN:  1091-5818     ISO Abbreviation:  Int. J. Toxicol.     Publication Date:  2001  
Date Detail:
Created Date:  2001-05-18     Completed Date:  2001-10-04     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  9708436     Medline TA:  Int J Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-20     Citation Subset:  IM    
Affiliation:
Cosmetic Ingredient Review, Washington, DC 20036, USA.
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MeSH Terms
Descriptor/Qualifier:
Acne Vulgaris / etiology,  pathology
Animals
Consumer Product Safety
Cosmetics / adverse effects*,  toxicity
Mud Therapy / adverse effects
Plant Extracts / adverse effects*,  toxicity
Plant Oils / adverse effects*,  chemistry,  toxicity
Seeds / adverse effects*,  chemistry,  toxicity
Skin / pathology
Skin Irritancy Tests
United States
Chemical
Reg. No./Substance:
0/Cosmetics; 0/Plant Extracts; 0/Plant Oils

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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