Document Detail

Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of dicarboxylic acids, salts, and esters.
MedLine Citation:
PMID:  22869895     Owner:  NLM     Status:  MEDLINE    
The CIR Expert Panel assessed the safety of dicarboxylic acids and their salts and esters as used in cosmetics. Most dicarboxylic acids function in cosmetics as pH adjusters or fragrance ingredients, but the functions of most of the salts in cosmetics are not reported. Some of the esters function as skin conditioning or fragrance ingredients, plasticizers, solvents, or emollients. The Expert Panel noted gaps in the available safety data for some of the dicarboxylic acid and their salts and esters in this safety assessment. The available data on many of the ingredients are sufficient, however, and similar structural activity relationships, biologic functions, and cosmetic product usage suggest that the available data may be extrapolated to support the safety of the entire group. The Panel concluded that the ingredients named in this report are safe in the present practices of use and concentration.
Monice M Fiume; Bart Heldreth; Hbart Eldreth; Wilma F Bergfeld; Donald V Belsito; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; F Alan Andersen
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Publication Detail:
Type:  Journal Article; Technical Report    
Journal Detail:
Title:  International journal of toxicology     Volume:  31     ISSN:  1092-874X     ISO Abbreviation:  Int. J. Toxicol.     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-08-07     Completed Date:  2013-01-25     Revised Date:  2013-02-13    
Medline Journal Info:
Nlm Unique ID:  9708436     Medline TA:  Int J Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5S-76S     Citation Subset:  IM    
Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA.
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MeSH Terms
Dicarboxylic Acids / adverse effects*,  chemistry,  pharmacokinetics
Esters / chemistry
Risk Assessment
Salts / chemistry
Reg. No./Substance:
0/Cosmetics; 0/Dicarboxylic Acids; 0/Esters; 0/Salts
Erratum In:
Int J Toxicol. 2012 Sep-Oct;31(5 Suppl):261S
Note: Eldreth, Hbart [corrected to Heldreth, Bart]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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