| Final report of the cosmetic ingredient review expert panel on the safety assessment of pelargonic Acid (nonanoic Acid) and nonanoate esters. | |
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MedLine Citation:
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PMID: 22247237 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Pelargonic acid and its esters function as skin-conditioning agents in cosmetics. Molecular weight (mw) and octanol-water partition coefficient data suggest that dermal penetration is possible. The biohandling of branched-chain fatty acids is not the same as for straight-chain fatty acids, but the differences are not significant to the conclusion that they all are readily metabolized to nontoxic moieties. Limited data suggested that the penetration of other ingredients may be enhanced if these ingredients are present in the same formulation. These ingredients are not significant oral or dermal toxicants in animal studies. They are not reproductive/developmental toxicants or genotoxic/carcinogenic in animal studies. The available data suggested that product formulations containing these ingredients would be nonirritating and nonsensitizing to human skin, but formulators were cautioned to consider the penetration enhancement potential. The Cosmetic Ingredient Review (CIR) Expert Panel concluded that these ingredients are safe in the present practices of use and concentration. |
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Authors:
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Wilbur Johnson; And Bart Heldreth; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; Ronald Hill; Daniel Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; F Alan Andersen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of toxicology Volume: 30 ISSN: 1092-874X ISO Abbreviation: Int. J. Toxicol. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-01-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708436 Medline TA: Int J Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 228S-69S Citation Subset: IM |
Affiliation:
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Cosmetic Ingredient Review, 1101 17th Street, NW, Suite, 412, Washington, DC 20036, USA Email: cirinfo@cir-safety.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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