| Final report of the amended safety assessment of myristic acid and its salts and esters as used in cosmetics. | |
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MedLine Citation:
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PMID: 20634506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report addresses the safety of the inorganic salts and esters of various fatty alcohols of myristic acid. Most of the esters are used as skin conditioning agents in many types of cosmetics in a range of concentrations. Myristate esters are readily hydrolyzed to the corresponding alcohols and acids, which are then further metabolized. Myristate salts readily dissociate in any likely cosmetic formulation. The Cosmetic Ingredient Review (CIR) Panel recognized that much of the data supporting the ingredients in this group were previously reviewed in safety assessments for related ingredients. Where specific data did not exist, the Panel considered structure-activity relationships in determining the safety of these ingredients as used in cosmetics. The Panel determined that myristic acid and its salts and esters are safe as cosmetic ingredients in the current practices of use and concentration. |
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Authors:
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Lillian C Becker; Wilma F Bergfeld; Donald V Belsito; Ronald A Hill; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; F Alan Andersen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: International journal of toxicology Volume: 29 ISSN: 1092-874X ISO Abbreviation: Int. J. Toxicol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-16 Completed Date: 2010-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708436 Medline TA: Int J Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 162S-86S Citation Subset: IM |
Affiliation:
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Cosmetic Ingredient Review, Washington, DC 20036, USA. cirinfo@cir-safety.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cosmetics* Esters Myristic Acid / chemistry, toxicity* Salts |
| Chemical | |
Reg. No./Substance:
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0/Cosmetics; 0/Esters; 0/Salts; 544-63-8/Myristic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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