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Final infarct volume estimation on 1-week follow-up MR imaging is feasible and is dependent on recanalization status.
MedLine Citation:
PMID:  25429356     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: We aim to characterize infarct volume evolution within the first month post-ischemic stroke and to determine the effect of recanalization status on early infarct volume estimation.
METHODS: Ischemic stroke patients recruited for the MONITOR and VISION studies were retrospectively screened and patients who had infarcts on diffusion-weighted imaging (DWI) at baseline and had at least two follow-up MR scans (n = 56) were included. Pre-defined target imaging time points, obtained on a 3-T MR scanner, were 12 hours (h), 24 h, 7 days, and ≥30 days post-stroke. Infarct tissue was manually traced blinded to the images at the other time points. Infarct expansion index was calculated by dividing infarct volume at each follow-up time point by the baseline DWI infarct volume. Recanalization was assessed within 24 h post-stroke. Correlation and statistical comparison analysis were done using the Spearman, Mann-Whitney, and Kruskal-Wallis tests.
RESULTS: Follow-up infarct volumes were positively correlated with the baseline infarct volume (ρ > 0.81; p < 0.001) where the strongest correlation existed between baseline and 7-day post-stroke infarct volumes (ρ = 0.92; p < 0.001). The strongest correlation among the follow-up imaging was found between infarct volumes 7-day post-stroke and ≥30-day time points (ρ = 0.93; p < 0.001). Linear regression showed a close-to unity slope between 7-day and final infarct volumes (slope = 1.043; p < 0.001). Infarct expansion was higher in the non-recanalized group than the recanalized group at the 7-day (p = 0.001) and ≥30-day (p = 0.038) time points.
CONCLUSIONS: Final infarct volume can be approximated as early as 7 days post-stroke. Final infarct volume approximation is significantly associated with recanalization status.
Authors:
Mark Krongold; Mohammed A Almekhlafi; Andrew M Demchuk; Shelagh B Coutts; Richard Frayne; Armin Eilaghi
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Publication Detail:
Type:  Journal Article     Date:  2014-11-08
Journal Detail:
Title:  NeuroImage. Clinical     Volume:  7     ISSN:  2213-1582     ISO Abbreviation:  Neuroimage Clin     Publication Date:  2015  
Date Detail:
Created Date:  2014-11-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101597070     Medline TA:  Neuroimage Clin     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
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