Document Detail

Final height after growth hormone therapy in short children: correlation with siblings' height.
MedLine Citation:
PMID:  9402245     Owner:  NLM     Status:  MEDLINE    
Sixteen prepubertal children (10 males, 6 females) were treated with growth hormone (GH) 0.75 U/kg/week for 4-5 years until final height was attained. Before initiation of GH therapy height was below 2 SDS for age and gender, growth velocity was <4.5 cm/year, bone age was more than 2 SD below the mean for age, and the GH response to provocative tests was more than 10 microg/l. The final height of 9 patients exceeded their predicted and target heights. The final height of the treated patients was highly correlated with their siblings' heights (r = 0.806, p < 0.001) and to a lesser degree with the target or the predicted height (r = 0.401, p = 0.124 and r = 0.465, p = 0.06, respectively). It is concluded that the secular trend should be taken into consideration when evaluating the success of GH therapy.
Z Zadik; A Zung
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Hormone research     Volume:  48     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1997  
Date Detail:
Created Date:  1998-01-30     Completed Date:  1998-01-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  274-7     Citation Subset:  IM    
Pediatric Endocrine Unit, Kaplan Hospital, Rehovot, Israel.
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MeSH Terms
Body Height / drug effects,  physiology*
Growth Disorders / drug therapy*
Growth Hormone / therapeutic use*
Sex Characteristics
Treatment Outcome
Reg. No./Substance:
9002-72-6/Growth Hormone

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