Document Detail

Final ART success rates: a 10 years survey.
MedLine Citation:
PMID:  21659314     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cumulative pregnancy rates (CPRs) and live birth rates (CLBRs) are much better indicators of success in IVF programmes than cross-sectional figures per cycle or embryo transfer. They allow a better estimation of patient's chances of having a child and enable comparisons between centres and treatment strategies.
METHODS: A 10 year cohort study of patients undergoing their first assisted reproductive technique cycle was conducted. Patients were followed until live birth or discontinuation of treatment. All IVF and ICSI cycles and cryo-cycles with embryos derived from frozen pronuclear stage oocytes were included. The CPR and CLBR were estimated using the Kaplan-Meier method for both the number of treatment cycles and transferred embryos. The analysis assumed that couples who did not return for subsequent treatment cycles would have had the same chance of success as those who had continued treatment.
RESULTS: A total of 3011 women treated between 1998 and 2007 were included, and 2068 children were born; women already with a live birth re-entered the analysis as a 'new patient'. For 3394 'patients under observation' with 8048 cycles, the CLBR was 52% after 3 cycles (the median number of cycles per patient), 72% after 6 cycles and 85% after 12 cycles. A CLBR of ∼ 50% was achieved for patients aged under 40 years, after the cumulative transfer of six embryos. The mean live birth rate from one fresh cycle and its subsequent cryo-cycle(s) was 33%. Our analysis also shows that ART can reach natural fertility rates but not exceed them.
CONCLUSIONS: Most couples with infertility problems can be treated successfully if they continue treatment. Thereby ART can reach natural fertility rates. Even with the restrictions in place as a result of the German Embryo Protection Law, CLBR reach internationally comparable levels.
C Gnoth; B Maxrath; T Skonieczny; K Friol; E Godehardt; J Tigges
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-09
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  26     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-18     Completed Date:  2011-12-07     Revised Date:  2012-05-25    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2239-46     Citation Subset:  IM    
Centre for Family Planning, Gynaecological Endocrinology and Reproductive Medicine, green-ivf, Department of Obstetrics and Gynaecology, University of Cologne, Rheydter Str 143, D-41515 Grevenbroich, Germany.
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MeSH Terms
Birth Rate
Cohort Studies
Fertilization in Vitro
Live Birth*
Oocyte Donation / statistics & numerical data
Pregnancy Rate*
Reproductive Techniques, Assisted / economics,  legislation & jurisprudence,  statistics & numerical data*
Sperm Injections, Intracytoplasmic / statistics & numerical data
Comment In:
Hum Reprod. 2012 May;27(5):1542; author reply 1542-3   [PMID:  22357764 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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