Document Detail

Fimbriae of Branhamella catarrhalis as possible mediators of adherence to pharyngeal epithelial cells.
MedLine Citation:
PMID:  1362885     Owner:  NLM     Status:  MEDLINE    
This study attempted to elucidate the role of fimbriae in the adherence of B. catarrhalis to human oropharyngeal epithelial cells. Antifimbrial immune serum was prepared by immunization of rabbit with whole fimbriated bacteria, and adsorption of the serum with a nonfimbriated B. catarrhalis strain. After pretreatment with the antifimbrial antiserum, the adherence of fimbriated B. catarrhalis to human epithelial cells was significantly decreased (p < 0.05). The adherence was also significantly (p < 0.001) decreased by trypsin treatment. Electron microscopy revealed destruction of fimbriae after trypsin treatment. These observations suggest that fimbriae are involved in the adherence of B. catarrhalis to epithelial cells.
K Ahmed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  100     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-03-10     Completed Date:  1993-03-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1066-72     Citation Subset:  IM    
Department of Internal Medicine, Nagasaki University, Japan.
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MeSH Terms
Bacterial Adhesion*
Blood Physiological Phenomena
Epithelium / microbiology
Fimbriae, Bacterial / physiology*
Microscopy, Electron
Moraxella (Branhamella) catarrhalis / pathogenicity,  physiology*,  ultrastructure
Pharynx / microbiology*
Trypsin / pharmacology
Reg. No./Substance:

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