Document Detail

FimZ is a molecular link between sticking and swimming in Salmonella enterica serovar Typhimurium.
MedLine Citation:
PMID:  11807085     Owner:  NLM     Status:  MEDLINE    
Salmonella enterica serovar Typhimurium produces two types of filamentous appendages on its surface. Fimbriae mediate adherence to tissues and cells via receptor-specific interactions, and flagella are the organelles of motility. These appendages play a role in colonization and dissemination, respectively, from infected surfaces and may be important components of bacterial survival. Increased expression of FimZ in serovar Typhimurium resulted in bacteria which were hyperfimbriated but were nonmotile in soft agar. This lack of motility was associated with down regulation of the flhDC master flagellar operon. Therefore, FimZ represents a molecular connection between flagella and fimbrial formation in serovar Typhimurium, indicating that the synthesis of flagella and fimbriae are oppositely controlled.
Steven Clegg; Kelly T Hughes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  184     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-24     Completed Date:  2002-03-19     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1209-13     Citation Subset:  IM    
Department of Microbiology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
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MeSH Terms
Bacterial Adhesion / physiology*
Bacterial Proteins / genetics,  physiology*
Culture Media
DNA Transposable Elements
DNA-Binding Proteins
Escherichia coli Proteins
Gene Expression
Salmonella typhimurium / genetics,  growth & development,  physiology*
Reg. No./Substance:
0/Bacterial Proteins; 0/Culture Media; 0/DNA Transposable Elements; 0/DNA-Binding Proteins; 0/Escherichia coli Proteins; 0/Trans-Activators; 0/flhC protein, E coli; 0/flhD protein, E coli; 138160-43-7/fimZ protein, Bacteroides nodosus; 9002-18-0/Agar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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