| FimZ is a molecular link between sticking and swimming in Salmonella enterica serovar Typhimurium. | |
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MedLine Citation:
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PMID: 11807085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Salmonella enterica serovar Typhimurium produces two types of filamentous appendages on its surface. Fimbriae mediate adherence to tissues and cells via receptor-specific interactions, and flagella are the organelles of motility. These appendages play a role in colonization and dissemination, respectively, from infected surfaces and may be important components of bacterial survival. Increased expression of FimZ in serovar Typhimurium resulted in bacteria which were hyperfimbriated but were nonmotile in soft agar. This lack of motility was associated with down regulation of the flhDC master flagellar operon. Therefore, FimZ represents a molecular connection between flagella and fimbrial formation in serovar Typhimurium, indicating that the synthesis of flagella and fimbriae are oppositely controlled. |
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Authors:
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Steven Clegg; Kelly T Hughes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of bacteriology Volume: 184 ISSN: 0021-9193 ISO Abbreviation: J. Bacteriol. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-01-24 Completed Date: 2002-03-19 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: United States |
Other Details:
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Languages: eng Pagination: 1209-13 Citation Subset: IM |
Affiliation:
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Department of Microbiology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. stevenclegg@uiowa.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Agar Bacterial Adhesion / physiology* Bacterial Proteins / genetics, physiology* Culture Media DNA Transposable Elements DNA-Binding Proteins Escherichia coli Proteins Gene Expression Mutagenesis Salmonella typhimurium / genetics, growth & development, physiology* Trans-Activators |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Culture Media; 0/DNA Transposable Elements; 0/DNA-Binding Proteins; 0/Escherichia coli Proteins; 0/Trans-Activators; 0/flhC protein, E coli; 0/flhD protein, E coli; 138160-43-7/fimZ protein, Bacteroides nodosus; 9002-18-0/Agar |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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