| Filtration for free drug level monitoring: carbamazepine and valproic acid. | |
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MedLine Citation:
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PMID: 6424279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Free carbamazepine and valproic acid monitoring using the EMIT FreeLevel filtration system was evaluated and compared with reference equilibrium dialysis and gas chromatographic (GC) techniques. For carbamazepine, free levels after filtration or dialysis were essentially identical (mean 1.74 vs. 1.77 mg/L, r = 0.940, n = 28, EMIT assay). Free levels were 16% higher by EMIT than by GC, possibly due to cross-reaction with carbamazepine-10,11-epoxide. Free fractions were not significantly different using any combination of filtration or dialysis with EMIT or GC (means 0.24-0.26). There was a significant correlation between epoxide and parent-drug free fractions (r = 0.642). Free fraction varied from 0.20 to 0.41 among 61 patient samples and was independent of total drug concentration. For valproic acid, there was a strong correlation between filtration and dialysis results for free level (r = 0.974) and free fraction (r = 0.892), but filtration values were 6-7% higher. Free fraction was concentration dependent (r = 0.597), and lower free fractions by dialysis were attributed to dilution of total drug concentration. Free fraction varied from 0.01 to 0.14 among 50 patient samples. For carbamazepine and valproic acid the EMIT FreeLevel filtration system compared favorably with equilibrium dialysis, and had the advantage of being rapid. |
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Authors:
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R H Levy; P N Friel; I Johno; L M Linthicum; L Colin; K Koch; V A Raisys; A J Wilensky; N R Temkin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Therapeutic drug monitoring Volume: 6 ISSN: 0163-4356 ISO Abbreviation: Ther Drug Monit Publication Date: 1984 |
Date Detail:
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Created Date: 1984-05-14 Completed Date: 1984-05-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7909660 Medline TA: Ther Drug Monit Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 67-76 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Proteins
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metabolism Carbamazepine / analogs & derivatives, blood* Chromatography, Gas Dialysis Filtration / methods Humans Protein Binding Valproic Acid / blood* |
| Grant Support | |
ID/Acronym/Agency:
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N01-NS-6-2341/NS/NINDS NIH HHS; NS 17111/NS/NINDS NIH HHS; RR-37/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 298-46-4/Carbamazepine; 36507-30-9/carbamazepine epoxide; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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