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Filovirus tropism: cellular molecules for viral entry.
MedLine Citation:
PMID:  22363323     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
In human and non-human primates, filoviruses (Ebola and Marburg viruses) cause severe hemorrhagic fever. Recently, other animals such as pigs and some species of fruit bats have also been shown to be susceptible to these viruses. While having a preference for some cell types such as hepatocytes, endothelial cells, dendritic cells, monocytes, and macrophages, filoviruses are known to be pantropic in infection of primates. The envelope glycoprotein (GP) is responsible for both receptor binding and fusion of the virus envelope with the host cell membrane. It has been demonstrated that filovirus GP interacts with multiple molecules for entry into host cells, whereas none of the cellular molecules so far identified as a receptor/co-receptor fully explains filovirus tissue tropism and host range. Available data suggest that the mucin-like region (MLR) on GP plays an important role in attachment to the preferred target cells, whose infection is likely involved in filovirus pathogenesis, whereas the MLR is not essential for the fundamental function of the GP in viral entry into cells in vitro. Further studies elucidating the mechanisms of cellular entry of filoviruses may shed light on the development of strategies for prophylaxis and treatment of Ebola and Marburg hemorrhagic fevers.
Authors:
Ayato Takada
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Publication Detail:
Type:  Journal Article     Date:  2012-02-06
Journal Detail:
Title:  Frontiers in microbiology     Volume:  3     ISSN:  1664-302X     ISO Abbreviation:  Front Microbiol     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-24     Completed Date:  2012-10-02     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101548977     Medline TA:  Front Microbiol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  34     Citation Subset:  -    
Affiliation:
Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University Sapporo, Japan.
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