Document Detail

Filovirus tropism: cellular molecules for viral entry.
MedLine Citation:
PMID:  22363323     Owner:  NLM     Status:  PubMed-not-MEDLINE    
In human and non-human primates, filoviruses (Ebola and Marburg viruses) cause severe hemorrhagic fever. Recently, other animals such as pigs and some species of fruit bats have also been shown to be susceptible to these viruses. While having a preference for some cell types such as hepatocytes, endothelial cells, dendritic cells, monocytes, and macrophages, filoviruses are known to be pantropic in infection of primates. The envelope glycoprotein (GP) is responsible for both receptor binding and fusion of the virus envelope with the host cell membrane. It has been demonstrated that filovirus GP interacts with multiple molecules for entry into host cells, whereas none of the cellular molecules so far identified as a receptor/co-receptor fully explains filovirus tissue tropism and host range. Available data suggest that the mucin-like region (MLR) on GP plays an important role in attachment to the preferred target cells, whose infection is likely involved in filovirus pathogenesis, whereas the MLR is not essential for the fundamental function of the GP in viral entry into cells in vitro. Further studies elucidating the mechanisms of cellular entry of filoviruses may shed light on the development of strategies for prophylaxis and treatment of Ebola and Marburg hemorrhagic fevers.
Ayato Takada
Related Documents :
17224623 - Amp-activated protein kinase and autophagy.
7764113 - Constant flowrate filtration of hybridoma cells suspensions.
1967073 - Regulation of mi transport in retinal pigment epithelium by sugars, amiloride, and ph g...
Publication Detail:
Type:  Journal Article     Date:  2012-02-06
Journal Detail:
Title:  Frontiers in microbiology     Volume:  3     ISSN:  1664-302X     ISO Abbreviation:  Front Microbiol     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-24     Completed Date:  2012-10-02     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101548977     Medline TA:  Front Microbiol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  34     Citation Subset:  -    
Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University Sapporo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Scavenger receptor b2 as a receptor for hand, foot, and mouth disease and severe neurological diseas...
Next Document:  Effects of nitrogen load on the function and diversity of methanotrophs in the littoral wetland of a...