| Fighting against age discrimination in clinical trials. | |
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MedLine Citation:
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PMID: 20863340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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At the American Geriatrics Society 2008 Annual Meeting, representatives of two geriatric societies, the European Union Geriatric Medicine Societies and the American Geriatrics Society, and two regulatory agencies, the U.S. Food and Drug Administration and the European Medicine Agency, conducted a roundtable discussion aimed at reviewing the participation of older people in clinical trials. This article summarizes the important issues discussed at the meeting. Historically, regulatory agencies started to promote the inclusion of older participants in clinical trials in the late 1980s. The identification of the causes of delay in including older participants in clinical trials, as well as of the ongoing bias against including older participants with multiple comorbidities, is important to help geriatricians fight against age discrimination in clinical trials. To overcome this problem, geriatrics societies and regulatory agencies must work together to propose new definitions, study designs, and technologies aimed at improving the evaluation of drugs in older people with multiple comorbidities and polypharmacy. |
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Authors:
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Antonio Cherubini; Susanna Del Signore; Joe Ouslander; Todd Semla; Jean-Pierre Michel |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of the American Geriatrics Society Volume: 58 ISSN: 1532-5415 ISO Abbreviation: J Am Geriatr Soc Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-24 Completed Date: 2010-10-12 Revised Date: 2010-10-19 |
Medline Journal Info:
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Nlm Unique ID: 7503062 Medline TA: J Am Geriatr Soc Country: United States |
Other Details:
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Languages: eng Pagination: 1791-6 Citation Subset: IM |
Copyright Information:
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© 2010, Copyright the Authors. Journal compilation © 2010, The American Geriatrics Society. |
Affiliation:
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Institute of Gerontology and Geriatrics, Perugia University Medical School, Policlinico Santa Maria della Misericordia, Perugia, Italy. cherubin_9@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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psychology* Clinical Trials as Topic / legislation & jurisprudence, methods* Ethics, Medical Geriatrics / legislation & jurisprudence* Humans Patient Selection* Prejudice* Societies, Medical* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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