Document Detail


Fig mosaic emaravirus p4 protein is involved in cell-to-cell movement.
MedLine Citation:
PMID:  23152372     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fig mosaic virus (FMV), a member of the newly formed genus Emaravirus, is a segmented negative-strand RNA virus. Each of the six genomic FMV segments contains a single open reading frame: that of RNA4 encodes the protein p4. FMV-p4 has been suggested to be the movement protein (MP) of the virus; however, direct experimental evidence for this is lacking. We assessed the intercellular distribution of FMV-p4 in plant cells by confocal laser scanning microscopy, and we found that FMV-p4 was localized to plasmodesmata and to the plasma membrane accompanied by tubule-like structures. A series of experiments designed to examine the movement functions revealed that FMV-p4 has the capacity to complement viral cell-to-cell movement, prompt sGFP diffusion between cells, and spread by itself to neighboring cells. Altogether, our findings demonstrated that FMV-p4 shares several properties with other viral MPs and plays important role in cell-to-cell movement.
Authors:
Kazuya Ishikawa; Kensaku Maejima; Ken Komatsu; Osamu Netsu; Takuya Keima; Takuya Shiraishi; Yukari Okano; Masayoshi Hashimoto; Yasuyuki Yamaji; Shigetou Namba
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  The Journal of general virology     Volume:  -     ISSN:  1465-2099     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
The University of Tokyo.
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