| Fifty-two months' mean follow up of decellularized SynerGraft-treated pulmonary valve allografts. | |
| | |
MedLine Citation:
|
PMID: 18365576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND AIM OF THE STUDY: It has been reported previously that the use of a decellularized pulmonary allograft (SynerGraft; CryoLife Inc.) for right ventricular outflow tract reconstruction in adults is associated with reduced immunization. The implantation appeared to be safe, but was not associated with any detectable clinical or echocardiographic advantage. The study aim was to follow further the outcome of SynerGraft patients. METHODS: Twenty-three adult patients (19 males, four females) each received a SynerGraft-allograft during a Ross procedure. A further 49 patients (37 males, 12 females) who underwent a Ross procedure using a conventional pulmonary allograft during the same period served as controls. Follow up examinations using transthoracic echocardiography in standard views was performed on a regular basis. The latest follow up was performed after a mean of 52 months. RESULTS: Directly after implantation, there were no echocardiographic differences between the two groups, but with time the pressure gradients increased significantly (p <0.001) in both groups. At the latest follow up, pressure gradients were slightly higher across the SynerGraft-allograft valves than across conventional allografts (Pmax 18.2 +/- 9.0 versus 14.0 +/- 6.9 mmHg, respectively; p = 0.049). On regression analysis (considering pre- and intraoperative variables), 'SynerGraft-allograft' was the only variable predicting the increase in pressure gradient from its postoperative value to that at follow up. However, no clinical differences were observed between the groups. CONCLUSION: The present results relate to the longest follow up on decellularized pulmonary SynerGraft-allografts conducted to date. No reoperations were required after a mean follow up of 52 months, and the echocardiographic results were stable after the first postoperative year. Based on these data, the use of pulmonary SynerGraft-allograft valves in adults appears not to provide any advantage over conventional allografts, although further follow up is warranted before any final judgment is made regarding this new technology. |
| | |
Authors:
|
J F Matthias Bechtel; Ulrich Stierle; Hans-Hinrich Sievers |
Related Documents
:
|
10356676 - Analysis of regurgitation, mean systolic pressure drop and energy losses for two artifi... 23256946 - Incidence, outcome and correlates of residual paravalvular aortic regurgitation after t... 3989136 - Mitral valve alternans. 2398586 - Significance and management of inflow gradients unexpectedly generated after femorofemo... 19864506 - Association of aortic arch pulse wave velocity with left ventricular mass and lacunar b... 8426006 - Effects of adenosine in combination with calcium channel blockers in patients with prim... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: The Journal of heart valve disease Volume: 17 ISSN: 0966-8519 ISO Abbreviation: J. Heart Valve Dis. Publication Date: 2008 Jan |
Date Detail:
|
Created Date: 2008-03-27 Completed Date: 2008-05-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9312096 Medline TA: J Heart Valve Dis Country: England |
Other Details:
|
Languages: eng Pagination: 98-104; discussion 104 Citation Subset: IM |
Affiliation:
|
Department for Cardiac and Thoracic Vascular Surgery, University of Luebeck, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Flow Velocity Cryopreservation / methods* Echocardiography, Doppler, Pulsed Female Follow-Up Studies Heart Valve Prosthesis Implantation / instrumentation* Humans Male Middle Aged Prosthesis Design Pulmonary Valve / transplantation* Retrospective Studies Suture Techniques Time Factors Transplantation, Homologous Treatment Outcome Ventricular Outflow Obstruction / physiopathology, surgery*, ultrasonography Ventricular Pressure / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Resuspension of the aortic valve in acute type A dissection: long-term results.
Next Document: In-vivo evaluation of the BioPhysio valve prosthesis in the aortic position.