| Fifteen weeks of dietary n-3 polyunsaturated fatty acid deprivation increase turnover of n-6 docosapentaenoic acid in rat-brain phospholipids. | |
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MedLine Citation:
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PMID: 22142872 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Docosapentaenoic acid (DPAn-6, 22:5n-6) is an n-6 polyunsaturated fatty acid (PUFA) whose brain concentration can be increased in rodents by dietary n-3 PUFA deficiency, which may contribute to their behavioral dysfunction. We used our in vivo intravenous infusion method to see if brain DPAn-6 turnover and metabolism also were altered with deprivation. We studied male rats that had been fed for 15 weeks post-weaning an n-3 PUFA adequate diet containing 4.6% alpha-linolenic acid (α-LNA, 18:3n-3) or a deficient diet (0.2% α-LNA), each lacking docosahexaenoic acid (22:6n-3) and arachidonic acid (AA, 20:4n-6). [1-(14)C]DPAn-6 was infused intravenously for 5min in unanesthetized rats, after which the brain underwent high-energy microwaving, and then was analyzed. The n-3 PUFA deficient compared with adequate diet increased DPAn-6 and decreased DHA concentrations in plasma and brain, while minimally changing brain AA concentration. Incorporation rates of unesterified DPAn-6 from plasma into individual brain phospholipids were increased 5.2-7.7 fold, while turnover rates were increased 2.1-4.7 fold. The observations suggest that increased metabolism and brain concentrations of DPAn-6 and its metabolites, together with a reduced brain DHA concentration, contribute to behavioral and functional abnormalities reported with dietary n-3 PUFA deprivation in rodents. (196 words). |
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Authors:
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Miki Igarashi; Hyung-Wook Kim; Fei Gao; Lisa Chang; Kaizong Ma; Stanley I Rapoport |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2011-11-30 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1821 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-07-16 Completed Date: 2013-02-15 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1235-43 Citation Subset: IM |
Copyright Information:
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Published by Elsevier B.V. |
Affiliation:
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National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. miki.i@uci.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism* Brain Chemistry Fatty Acids, Omega-3* Fatty Acids, Unsaturated / metabolism* Male Phospholipids / immunology* Rats Rats, Inbred F344 Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 25448-00-4/docosapentaenoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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